Académicos del Departamento
Facultad de Medicina, UNAM
Dr. Martin González Andrade
Facultad de Medicina. Torre de Investigación 3er piso
Tel. +52 (55) 56232254
En los últimos años, la línea de investigación que he desarrollado en la Facultad de Medicina (FM) de la UNAM se ha enfocado en el desarrollo de biosensores fluorescentes. Este proyecto de investigación corresponde a una línea de investigación nueva en el departamento de bioquímica de la FM de la UNAM. Estos estudios se han centrado en el desarrollo de biosensores fluorescentes de la proteína calmodulina (CaM) como herramientas de investigación bioquímica para el estudio de las interacciones proteína-proteína, proteína-péptido y en la búsqueda de nuevas entidades moleculares con propiedades bioactivas.
De manera complementaria realizo estudios de modelaje molecular (dinámica molecular, acoplamiento molecular “docking”, relación estructura actividad, etc.) para tratar de explicar a través de modelos estructurales las interacciones de estos sistemas con sus ligandos.
Experiencia Profesional
Líneas de Investigación
- Desarrollo de biosensores fluorescentes de la proteína calmodulina (CaM) como herramientas de investigación bioquímica
- Estudios básicos de las interacciones del sistema Calmodulina-péptidos para el desarrollo de biofármacos
- Desarollo de fármacos antideabéticos, utilizando las proteinas PTP1B y alfa-glucosidasa como blancos moleculares
- Estudios teóricos de interacciones macromoleculares con ligando, utilizando herramientas de modelaje molecular (dinámica molecular y docking)
- Cribado virtual basado en estructura y acoplamiento molecular
- Estudio de los principales metabolitos de la cannabis como fuente potencial de nuevos fármacos
- Panorama general de la industria farmacéutica y la farmacia comunitaria en México
Trayectoria profesional
- Profesor Titular “B” de TC, Departamento de Bioquímica, Facultad de Medicina, UNAM
- Profesor del Posgrado en Ciencias Bioquímicas (HERRAMIENTAS DE MODELAJE MOLECULAR APLICADAS A LAS INTERACCIONES BIOMOLECULARES), Facultad de Medicina, UNAM
- Investigador en Ciencias Médicas, Consorcio Estructura de Proteínas, Instituto Nacional de Medicina Genómica INMEGEN
Formación académica
- Doctorado en Ciencias Bioquímicas, Facultad de Medicina, UNAM (2006-2009)
- Maestro en Ciencias Bioquímicas, Facultad de Medicina, UNAM (2004-2006)
- Químico Farmacéutico Biólogo, Facultad de Estudios Superiores Zaragoza, UNAM (1998-2003)
Posdoctorados y estancias
- Estancia Posdoctoral en el Departamento de Farmacia, Facultad de Química, UNAM (2009-2011)
- Estancia de Investigación, Departamento de Química Analítica Facultad de Ciencias Químicas, Universidad Complutense de Madrid, España. En el grupo de sensores químicos ópticos y fotoquímica aplicada GSOLFA, http://www.gsolfa.info/ (2008-2009)
Premios y Distinciones
2024-2028
Miembro del Sistema Nacional de Investigadores Nivel II
2025-2029
PRIDE D
2019
Mención honorífica por estudios de Doctorado
2016
Mención honorífica por estudios de Maestría
Servicios de Modelaje Molecuar
Laboratorio de Biosensores y Modelaje molecular
Torre de Investigaciòn 3er piso
Departamento de Bioquìmica, Facultad de Medicna, UNAM
Alumnos
MC Rodolfo Aarón Lizárraga Valadez
Doctorado en Ciencias Biomédicas
Dr. Jonathan Trapala Reyna
Pos-Doctorado
Daniela Paola Barajas Arellano
PECEM
Abigail García Olvera
AFINES
Natalia Danae Pinzon Zuñiga
AFINES
Sofia Rueda Mercado
AFINES
Elisa Vivanco Bonilla
AFINES
Publicaciones
Change in selectivity of estrogen receptor alpha ligand-binding domain by mutations at residues H524/L525.
(2025) Biochim Biophys Acta Gen Subj. 1869, 130775
Pubmed
Biochim Biophys Acta Gen Subj
Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13-cis-Retinoic Acid is a PTP1B Inhibitor.
(2024) ChemMedChem. 19, e202400452
Pubmed
ChemMedChem
PMC Article
Exploring the role of the residues into catalytic cavity of inulosucrase from Leuconostoc citreum CW28.
(2024) Int J Biol Macromol. 279, 135159
Pubmed
Int J Biol Macromol
3-Benzylaminomethyl Lithocholic Acid Derivatives Exhibited Potent and Selective Uncompetitive Inhibitory Activity Against Protein Tyrosine Phosphatase 1B (PTP1B).
(2024) ACS Omega. 9, 33224-33238
Pubmed
ACS Omega
PMC Article
Chemical Analysis and Antidiabetic Potential of a Decoction from Roots.
(2024) J Nat Prod. 87, 501-513
Pubmed
J Nat Prod
The importance of including the C-terminal domain of PTP1B to identify potential antidiabetic inhibitors.
(2023) J Enzyme Inhib Med Chem. 38, 2170369
Pubmed
J Enzyme Inhib Med Chem
PMC Article
Anti-Diabetic Activity of Glycyrrhetinic Acid Derivatives FC-114 and FC-122: Scale-Up, In Silico, In Vitro, and In Vivo Studies.
(2023) Int J Mol Sci. 24,
Pubmed
Int J Mol Sci
PMC Article
Relevance of aromatic and polar amino acids in the specificity of Inulinase ISO3 from Kluyveromyces marxianus: A molecular dynamics approach with an experimental verification.
(2023) Int J Biol Macromol. 242, 124734
Pubmed
Int J Biol Macromol
Protein tyrosine phosphatase 1B inhibitory activity of compounds from Justicia spicigera (Acanthaceae).
(2022) Phytochemistry. 203, 113410
Pubmed
Phytochemistry
Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents.
(2022) J Biomol Struct Dyn. 40, 2689-2700
Pubmed
J Biomol Struct Dyn
Mitochondrial Calcium: Effects of Its Imbalance in Disease.
(2022) Antioxidants (Basel). 11,
Pubmed
Antioxidants (Basel)
PMC Article
The K-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms.
(2022) Int J Mol Sci. 23,
Pubmed
Int J Mol Sci
PMC Article
α-Glucosidase and PTP-1B Inhibitors from .
(2021) ACS Omega. 6, 22969-22981
Pubmed
ACS Omega
PMC Article
Indole- and Pyrazole-Glycyrrhetinic Acid Derivatives as PTP1B Inhibitors: Synthesis, In Vitro and In Silico Studies.
(2021) Molecules. 26,
Pubmed
Molecules
PMC Article
Protein tyrosine phosphatase 1B inhibitors from the fungus Malbranchea albolutea.
(2021) Phytochemistry. 184, 112664
Pubmed
Phytochemistry
TYK2 Variants in B-Acute Lymphoblastic Leukaemia.
(2020) Genes (Basel). 11,
Pubmed
Genes (Basel)
PMC Article
Dimeric phenalenones from Talaromyces sp. (IQ-313) inhibit hPTP1B: Insights into mechanistic kinetics from in vitro and in silico studies.
(2020) Bioorg Chem. 101, 103893
Pubmed
Bioorg Chem
Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Ortega.
(2020) Molecules. 25,
Pubmed
Molecules
PMC Article
α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from .
(2020) J Nat Prod. 83, 675-683
Pubmed
J Nat Prod
Additional α-glucosidase inhibitors from Malbranchea flavorosea (Leotiomycetes, Ascomycota).
(2018) J Antibiot (Tokyo). 71, 862-871
Pubmed
J Antibiot (Tokyo)
Differential modulation of human GABA-ρ1 receptor by sulfur-containing compounds structurally related to taurine.
(2018) BMC Neurosci. 19, 47
Pubmed
BMC Neurosci
PMC Article
Correction to α-Glucosidase Inhibitors from Brickellia cavanillesii.
(2017) J Nat Prod. 80, 233
Pubmed
J Nat Prod
A structural model for facultative anion channels in an oligomeric membrane protein: the yeast TRK (K(+)) system.
(2015) Pflugers Arch. 467, 2447-60
Pubmed
Pflugers Arch
Calmodulin inhibitors from natural sources: an update.
(2015) J Nat Prod. 78, 576-86
Pubmed
J Nat Prod
The N-terminal strand modulates immunoglobulin light chain fibrillogenesis.
(2014) Biochem Biophys Res Commun. 443, 495-9
Pubmed
Biochem Biophys Res Commun
Metabolites from the endophytic [corrected] fungus Sporormiella minimoides isolated from Hintonia latiflora.
(2013) Phytochemistry. 96, 273-8
Pubmed
Phytochemistry
Synthesis, docking study and relaxant effect of 2-alkyl and 2-naphthylchromones on rat aorta and guinea-pig trachea through phosphodiesterase inhibition.
(2013) Bioorg Chem. 50, 17-25
Pubmed
Bioorg Chem
Thielavins A, J and K: α-Glucosidase inhibitors from MEXU 27095, an endophytic fungus from Hintonia latiflora.
(2013) Phytochemistry. 94, 198-205
Pubmed
Phytochemistry
Absolute configuration of acremoxanthone C, a potent calmodulin inhibitor from Purpureocillium lilacinum.
(2013) J Nat Prod. 76, 1454-60
Pubmed
J Nat Prod
Importance of the interaction protein-protein of the CaM-PDE1A and CaM-MLCK complexes in the development of new anti-CaM drugs.
(2013) J Mol Recognit. 26, 165-74
Pubmed
J Mol Recognit
Calmodulin inhibitors from Aspergillus stromatoides.
(2013) Chem Biodivers. 10, 328-37
Pubmed
Chem Biodivers
(+)-Ascosalitoxin and vermelhotin, a calmodulin inhibitor, from an endophytic fungus isolated from Hintonia latiflora.
(2012) J Nat Prod. 75, 1571-7
Pubmed
J Nat Prod
α-glucosidase inhibitors from Brickellia cavanillesii.
(2012) J Nat Prod. 75, 968-74
Pubmed
J Nat Prod
Biosensor for on-line fluorescent detection of trifluoroperazine based on genetically modified calmodulin.
(2012) Anal Bioanal Chem. 402, 3211-8
Pubmed
Anal Bioanal Chem
Synthesis, biological evaluation, and docking studies of gigantol analogs as calmodulin inhibitors.
(2011) Eur J Med Chem. 46, 2699-708
Pubmed
Eur J Med Chem
Gnaphaliin A and B relax smooth muscle of guinea-pig trachea and rat aorta via phosphodiesterase inhibition.
(2011) J Pharm Pharmacol. 63, 926-35
Pubmed
J Pharm Pharmacol
Fluorescence, circular dichroism, NMR, and docking studies of the interaction of the alkaloid malbrancheamide with calmodulin.
(2011) J Enzyme Inhib Med Chem. 26, 378-85
Pubmed
J Enzyme Inhib Med Chem
Development of the fluorescent biosensor hCalmodulin (hCaM)L39C-monobromobimane(mBBr)/V91C-mBBr, a novel tool for discovering new calmodulin inhibitors and detecting calcium.
(2011) J Med Chem. 54, 3875-84
Pubmed
J Med Chem
An alternative assay to discover potential calmodulin inhibitors using a human fluorophore-labeled CaM protein.
(2009) Anal Biochem. 387, 64-70
Pubmed
Anal Biochem
Calmodulin inhibitors from the fungus Emericella sp.
(2009) Bioorg Med Chem. 17, 2167-74
Pubmed
Bioorg Med Chem
Site-directed fluorescence labeling reveals differences on the R-conformer of glucosamine 6-phosphate deaminase of Escherichia coli induced by active or allosteric site ligands at steady state.
(2005) Biochemistry. 44, 15083-92
Pubmed
Biochemistry
Correction: Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor.
(2019) PLoS One. 14, e0223795
Pubmed
PLoS One
PMC Article
Discovery of inhibitors of protein tyrosine phosphatase 1B contained in a natural products library from Mexican medicinal plants and fungi using a combination of enzymatic and methods*.
(2023) Front Pharmacol. 14, 1281045
Pubmed
Front Pharmacol
PMC Article
Differential Functionalization of Presumed and Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions.
(2018) Front Microbiol. 9, 944
Pubmed
Front Microbiol
PMC Article
Effect of N-Benzylpiperazine, Its Metabolite N-Benzylethylenediamine, and Its Disubstituted Analogue N,N'-Dibenzylpiperazine on the Acquisition, Formation, and Consolidation of Memory in Mice.
(2017) Pharmacology. 99, 268-274
Pubmed
Pharmacology
Insights into molecular interactions between CaM and its inhibitors from molecular dynamics simulations and experimental data.
(2016) J Biomol Struct Dyn. 34, 78-91
Pubmed
J Biomol Struct Dyn
Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor.
(2019) PLoS One. 14, e0220098
Pubmed
PLoS One
PMC Article
