Académicos del Departamento
Facultad de Medicina, UNAM
Dr. Yonathan Omar Garfias Becerra
La medicina regenerativa en el sistema visual ha ido tomando cada vez más importancia debido a diversos factores, uno de ellos es la investigación sobre células troncales. En nuestro laboratorio estamos interesados en la identificación de marcadores específicos de células troncales que tenga utilidad en la regeneración del sistema visual, principalmente en la superficie ocular. De la misma manera estamos investigando el impacto de éstas células sobre la inmunidad innata, principalmente en la activación de los neutrófilos y la repercusión en el proceso salud-enfermedad. Además nos estamos dedicando al estudio de las propiedades inmunorreguladoras de la membrana amniótica, tejido avascular que por sus propias características es inmunoprivilegiado, por lo que se puede trasplantar sin que provoque rechazo inmunológico sobre el receptor.
Por otra parte, el estudio de blancos terapéuticos para inhibir la neovascularización en el sistema visual es otra área de interés de nuestro laboratorio, para ello contamos con modelos celulares y animales que nos permitan identificar las moléculas de interés para disminuir el proceso de angiogénsesis en el sistema visual.
Experiencia Profesional
Líneas de Investigación
- Investigación sobre la biología celular de células troncales en el sistema de la visión
- Estudio de blancos terapéuticos para inhibir la angiogénesis en el sistema de la visión
Trayectoria profesional
- Profesor Titular “C” TC, PRIDE D, SNI 3, Departamento de Bioquímica, Facultad de Medicina, UNAM desde 2000
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Responsable de la Unidad Periférica Instituto de Oftalmología Conde de Valenciana – UNAM
https://di.facmed.unam.mx/
Unidad-de-Investigacion- Fundacion-Conde-de-Valenciana. php https://www.
condeinvestigacion.org/ biologia-celular-y-tisular/
Formación académica
- Doctorado en Ciencias, Facultad de Medicina, UNAM (1998-2003)
- Medico Cirujano, Facultad de Medicina, UNAM (1992-1998)
Posdoctorados y estancias
- Estancia doctoral Departamento de Patología, Universidad de Tufts, Boston MA, EUA
- Investigador Invitado, Insitut de la Vision-Univeristé Pierre et Marie Curie Paris VI, Francia
Colaboradores
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Dr. Alfredo Domínguez López, Profesor Asociado C, TC
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Dr. Óscar Vivanco Rojas, Técnico Académico C, TC
Premios y Distinciones
2019
Galardonado con el reconocimiento al Mérito Docente José Laguna García
2022
Medalla Gustavo Baz “2022” como asesor de la alumna Paola de Jesús Sánchez Cisneros
Alumnos

Carlos Abilio Sánchez Mojica
Estudiante de Maestría

Luis Andrés Haro Morlett
Estudiante de Especialidad

Alan Chew Bonila
Estudiante de Especialidad

Emilio Iturriaga Goyon
Estudiante de Doctorado

Gibrán Alejandro Estúa Acosta
Estudiante de doctorado

Alicia Demi Martínez Guzmán
AFINES

Diego Cerbón Higuera
AFINES

Norma Angélica Magaña Guerrero
MPSS
Publicaciones
2026 (3)
- Ramírez Hernández E, Netzahualcoyotzi C, Hurtado-Alvarado G, Sánchez JL, Pereyra Morales A, Arredondo-Zamarripa D, Hernández-Zimbrón LF, Papy-Garcia D, Guevara J, Gutiérrez Ponce N, Gomez-Henao W, Garfias Y, et al.. The Effect of Metabolic Syndrome on Alzheimer's Disease: Physical Activity as a Preventive and Therapeutic Measure. Brain sciences. 2026;16(5). DOI · PubMed · PMID: 42192778
- Domínguez-López A, Buentello-Volante B, Magaña-Guerrero N, Magaña-Guerrero FS, Vivanco-Rojas Ó, Graue Hernández EO, Garfias Y. Uses of Autologous Serum in Ocular Surface Diseases: A 10-Year Experience and Review of the Literature. Seminars in ophthalmology. 2026;41(3):471-478. DOI · PubMed · PMID: 40624617
- Magaña-Guerrero FS, Buentello-Volante B, Magaña-Guerrero NA, Vivanco-Rojas Ó, Domínguez-López A, Garfias Y. The NFAT5-AR Axis Is Associated with Hyperosmolarity, Renal Dysfunction, and Neutrophil-Related Inflammatory Markers in Diabetic Retinopathy. International journal of molecular sciences. 2026;27(2). DOI · PubMed · PMID: 41596742
2025 (4)
- Benedetti MD, Lenze M, García MR, Magaña Guerrero SF, Wikinski S, Garfias Y, Gutiérrez ML. Isolation and characterization of bovine Limbal mesenchymal stromal cells for application in ocular toxicity studies. Toxicology in vitro : an international journal published in association with BIBRA. 2025;109:106125. DOI · PubMed · PMID: 40749951
- Magaña-Guerrero FS, Bonilla AC, Buentello-Volante B, Magaña-Guerrero NA, Vivanco-Rojas O, Domínguez-López A, López-Bolaños A, Graue-Wiechers F, Garfias Y. Vitreous from patients with proliferative diabetic retinopathy induced changes in neutrophil activation markers. Molecular vision. 2025;31:368-378. PubMed · PMID: 41867378
- Vivanco-Rojas Ó, Ramírez-Hernández E, Zenteno E, Buentello-Volante B, Magaña-Guerrero FS, Domínguez-López A, Segura-Pérez E, Sánchez-Salgado JL, Pereyra-Morales MA, Garfias Y. Characterization of corneal and retinal changes in a metabolic syndrome model in young and adult mice. Experimental eye research. 2025;258:110496. DOI · PubMed · PMID: 40578593
- Domínguez-López A, Magaña-Guerrero FS, Buentello-Volante B, Vivanco-Rojas Ó, Garfias Y. NFAT5: a stress-related transcription factor with multiple functions in health and disease. Cell stress. 2025;9:16-48. DOI · PubMed · PMID: 40421201
2024 (3)
- Domínguez-López A, Navas A, Graue-Hernández EO, Perez VL, Garfias Y. Editorial: Dry eye disease syndrome, volume II. Frontiers in medicine. 2024;11:1520176. DOI · PubMed · PMID: 39640969
- Nava-Castañeda Á, Garnica-Hayashi L, Santiago-Rea N, González-Mondragón E, Buentello-Volante B, Magaña-Guerrero FS, Garfias Y. The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up. Translational vision science & technology. 2024;13(9):10. DOI · PubMed · PMID: 39235403
- López-Letayf S, Vivanco-Rojas O, Londoño-Angarita V, Magaña-Guerrero FS, Buentello-Volante B, Garfias Y. Intravitreal Antiangiogenic Treatment for Diabetic Retinopathy: A Mexican Real-Life Scenario Experience. Life (Basel, Switzerland). 2024;14(8). DOI · PubMed · PMID: 39202715
2023 (6)
- Hernández-Aceves JA, Cervantes-Torres J, Torres-García D, Zuñiga-Flores FJ, Patiño-Chávez OJ, Peña Agudelo JA, Aguayo-Flores JE, Garfias Y, Montero-León L, Romero-Romero L, Pérez-Torres A, Fragoso G, et al.. GK-1 effectively reduces angiogenesis and prevents T cell exhaustion in a breast cancer murine experimental model. Cancer immunology, immunotherapy : CII. 2023;72(11):3825-3838. DOI · PubMed · PMID: 37736849
- Vivanco-Rojas O, López-Letayf S, Londoño-Angarita V, Magaña-Guerrero FS, Buentello-Volante B, Garfias Y. Risk Factors for Diabetic Retinopathy in Latin America (Mexico) and the World: A Systematic Review and Meta-Analysis. Journal of clinical medicine. 2023;12(20). DOI · PubMed · PMID: 37892721
- Garfias Y, Magaña-Guerrero FS, Buentello-Volante B, Cruz Vega IB, Castro Salas I, Sánchez Cisneros PJ, Aguayo Flores JE, Salas Lais AG, Muñoz Medina JE, Mata-Haro V, Reséndiz-Sandoval M, Vázquez-García VA, et al.. Seroprevalence of SARS-CoV-2 in Mexican Health Care Workers after Two Years of the Pandemic: The Picture of an Ophthalmic Medical Centre. Ophthalmic epidemiology. 2023;30(4):400-406. DOI · PubMed · PMID: 36184872
- Magaña-Guerrero FS, Aguayo-Flores JE, Buentello-Volante B, Zarco-Ávila K, Sánchez-Cisneros P, Castro-Salas I, De la Torre-Galván E, Rodríguez-Loaiza JL, Jiménez-Corona A, Garfias Y. Spontaneous Neutrophil Extracellular Traps Release Are Inflammatory Markers Associated with Hyperglycemia and Renal Failure on Diabetic Retinopathy. Biomedicines. 2023;11(7). DOI · PubMed · PMID: 37509431
- Sámano-Hernández L, Y G, González-Márquez H, Corazón-Martínez LA, Lucio Vm BD. Human papilloma virus presence and its physical status in primary pterygium. Heliyon. 2023;9(5):e16189. DOI · PubMed · PMID: 37234612
- Salcedo-Ledesma A, Córdoba A, Zatarain-Barrón NC, Graue-Hernández EO, Garfias Y, Morales Flores N, García-Sánchez GA, García-Santisteban D, Linares-Alba MA, García-Santisteban R, Navas A. Subconjunctival Sirolimus-Loaded Liposomes for the Treatment of Moderate-to-Severe Dry Eye Disease. Clinical ophthalmology (Auckland, N.Z.). 2023;17:1295-1305. DOI · PubMed · PMID: 37181078
2022 (6)
- Navas A, Graue-Hernández EO, Perez VL, Garfias Y. Editorial: Dry eye disease syndrome. Frontiers in medicine. 2022;9:1104593. DOI · PubMed · PMID: 36687451
- Domínguez-López A, Garfias Y. Cytokine profile of human limbal myofibroblasts: Key players in corneal antiviral response. Cytokine. 2022;160:156047. DOI · PubMed · PMID: 36183616
- Haro-Morlett L, Magaña-Guerrero FS, Volante BB, Garfias Y. Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature. Journal of visualized experiments : JoVE. 2022. DOI · PubMed · PMID: 36314811
- Magaña-Guerrero FS, Trujillo DH, Buentello-Volante B, Aguayo-Flores JE, Melgoza-González EA, Hernández J, Jiménez-Martínez MC, Pérez-Tapia SM, Garfias Y. SARS-CoV-2 Seroprevalence among the Health Care Staff of an Ophthalmological Reference Centre, a Cross Sectional Study. Ophthalmic epidemiology. 2022;29(5):483-490. DOI · PubMed · PMID: 34530684
- Estúa-Acosta GA, Buentello-Volante B, Magaña-Guerrero FS, Flores JE, Vivanco-Rojas O, Castro-Salas I, Zarco-Ávila K, García-Mejía MA, Garfias Y. Human Amniotic Membrane Mesenchymal Stem Cell-Synthesized PGE(2) Exerts an Immunomodulatory Effect on Neutrophil Extracellular Trap in a PAD-4-Dependent Pathway through EP2 and EP4. Cells. 2022;11(18). DOI · PubMed · PMID: 36139406
- Cubillo-Martínez AA, Pereyra MA, Garfias Y, Guluarte C, Zenteno E, Sánchez-Salgado JL. Extracellular traps involved in invertebrate immune mechanisms. Fish & shellfish immunology. 2022;121:380-386. DOI · PubMed · PMID: 35045319
2021 (5)
- Iturriaga-Goyon E, Vivanco-Rojas O, Magaña-Guerrero FS, Buentello-Volante B, Castro-Salas I, Aguayo-Flores JE, Gracia-Mora I, Rivera-Huerta M, Sánchez-Bartés F, Garfias Y. AS1411 Nucleolin-Specific Binding Aptamers Reduce Pathological Angiogenesis through Inhibition of Nucleolin Phosphorylation. International journal of molecular sciences. 2021;22(23). DOI · PubMed · PMID: 34884955
- Quevedo-Martínez JU, Garfias Y, Jimenez J, Garcia O, Venegas D, Bautista de Lucio VM. Pro-inflammatory cytokine profile is present in the serum of Mexican patients with different stages of diabetic retinopathy secondary to type 2 diabetes. BMJ open ophthalmology. 2021;6(1):e000717. DOI · PubMed · PMID: 34263060
- Domínguez-López A, Magaña-Guerrero FS, Buentello-Volante B, Bautista-Hernández LA, Reyes-Grajeda JP, Bautista-de Lucio VM, Garfias Y. Amniotic membrane conditioned medium (AMCM) reduces inflammatory response on human limbal myofibroblast, and the potential role of lumican. Molecular vision. 2021;27:370-383. PubMed · PMID: 34447239
- Iturriaga-Goyon E, Buentello-Volante B, Magaña-Guerrero FS, Garfias Y. Future Perspectives of Therapeutic, Diagnostic and Prognostic Aptamers in Eye Pathological Angiogenesis. Cells. 2021;10(6). DOI · PubMed · PMID: 34200613
- López S, Hoz L, Tenorio EP, Buentello B, Magaña FS, Wintergerst A, Navas A, Garfias Y, Arzate H. Can Human Oral Mucosa Stem Cells Differentiate to Corneal Epithelia?. International journal of molecular sciences. 2021;22(11). DOI · PubMed · PMID: 34205905
2020 (6)
- Haber A, Polania-Baron EJ, Bolaños-Jimenez R, Navas A, Graue Hernandez EO, Garfias Y. Analysis of CCR3 expression in corneal neovascularization in a murine model and human corneas. Experimental eye research. 2020;197:108076. DOI · PubMed · PMID: 32485201
- Buentello-Volante B, Molina-Medinilla M, Aguayo-Flores E, Magaña-Guerrero FS, Garfias Y. Comparison of amniotic membrane transplantation and carpal tunnel syndrome release surgery (CTRS) and CTRS alone: Clinical outcomes at 1-year follow-up. Journal of tissue engineering and regenerative medicine. 2020;14(5):714-722. DOI · PubMed · PMID: 32174033
- Serna-Ojeda JC, García-Mejía M, Graue-Hernández EO, Navas A, Garfias Y. Short-Term Results Analysis in the Allogenic Transplantation of Limbal Stem Cells Expanded on Amniotic Membrane in Patients with Bilateral Limbal Stem Cell Deficiency. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2020;36(4):238-246. DOI · PubMed · PMID: 32077779
- Vivanco-Rojas O, García-Bermúdez MY, Iturriaga-Goyon E, Rebollo W, Buentello-Volante B, Magaña-Guerrero FS, Bates P, Pérez-Torres A, Garfias Y. Corneal neovascularization is inhibited with nucleolin-binding aptamer, AS1411. Experimental eye research. 2020;193:107977. DOI · PubMed · PMID: 32081668
- Arroyo R, López S, Romo E, Montoya G, Hoz L, Pedraza C, Garfias Y, Arzate H. Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/β-catenin Signaling in Human Oral Mucosa Stem Cells. International journal of molecular sciences. 2020;21(4). DOI · PubMed · PMID: 32075221
- Magaña-Guerrero FS, Quiroz-Mercado J, Garfias-Zenteno N, Garfias Y. Comparative analysis of inflammatory response in the BALB/c and C57BL/6 mouse strains in an endotoxin-induced uveitis model. Journal of immunological methods. 2020;476:112677. DOI · PubMed · PMID: 31626758
2019 (1)
- Estúa-Acosta GA, Zamora-Ortiz R, Buentello-Volante B, García-Mejía M, Garfias Y. Neutrophil Extracellular Traps: Current Perspectives in the Eye. Cells. 2019;8(9). DOI · PubMed · PMID: 31461831
2018 (2)
- Navas A, Magaña-Guerrero FS, Domínguez-López A, Chávez-García C, Partido G, Graue-Hernández EO, Sánchez-García FJ, Garfias Y. Anti-Inflammatory and Anti-Fibrotic Effects of Human Amniotic Membrane Mesenchymal Stem Cells and Their Potential in Corneal Repair. Stem cells translational medicine. 2018;7(12):906-917. DOI · PubMed · PMID: 30260581
- Meza-Cuenca F, Medina-Contreras JML, Mailloux-Salinas P, Bautista-Hernández LA, Buentello-Volante B, Domínguez-López A, Garfias Y, Correa-López PV, Bautista de Lucio VM, Bravo G. Characterization of free fatty acid receptors expression in an obesity rat model with high sucrose diet. Journal of receptor and signal transduction research. 2018;38(1):76-82. DOI · PubMed · PMID: 29369009
2017 (1)
- Magaña-Guerrero FS, Domínguez-López A, Martínez-Aboytes P, Buentello-Volante B, Garfias Y. Human Amniotic Membrane Mesenchymal Stem Cells inhibit Neutrophil Extracellular Traps through TSG-6. Scientific reports. 2017;7(1):12426. DOI · PubMed · PMID: 28963485
2016 (2)
- Quiroz-Mercado J, Ramírez-Velázquez N, Partido G, Zenteno E, Chávez R, Agundis-Mata C, Jiménez-Martínez MC, Garfias Y. Tissue and cellular characterisation of nucleolin in a murine model of corneal angiogenesis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2016;254(9):1753-63. DOI · PubMed · PMID: 27313162
- Chávez-García C, Jiménez-Corona A, Graue-Hernández EO, Zaga-Clavellina V, García-Mejía M, Jiménez-Martínez MC, Garfias Y. Ophthalmic indications of amniotic membrane transplantation in Mexico: an eight years Amniotic Membrane Bank experience. Cell and tissue banking. 2016;17(2):261-8. DOI · PubMed · PMID: 26675894
2015 (5)
- Hernández-Bogantes E, Amescua G, Navas A, Garfias Y, Ramirez-Miranda A, Lichtinger A, Graue-Hernández EO. Minor ipsilateral simple limbal epithelial transplantation (mini-SLET) for pterygium treatment. The British journal of ophthalmology. 2015;99(12):1598-600. DOI · PubMed · PMID: 26130669
- Arenas-Del Ángel M, Legorreta-Herrera M, Mendoza-Hernández G, Garfias Y, Chávez R, Zenteno E, Lascurain R. Amaranthus leucocarpus lectin recognizes a moesin-like O-glycoprotein and costimulates murine CD3-activated CD4(+) T cells. Immunity, inflammation and disease. 2015;3(3):182-95. DOI · PubMed · PMID: 26417436
- Bolaños-Jiménez R, Navas A, López-Lizárraga EP, de Ribot FM, Peña A, Graue-Hernández EO, Garfias Y. Ocular Surface as Barrier of Innate Immunity. The open ophthalmology journal. 2015;9:49-55. DOI · PubMed · PMID: 26161163
- Magaña D, Aguilar G, Linares M, Ayala-Balboa J, Santacruz C, Chávez R, Estrada-Parra S, Garfias Y, Lascurain R, Jiménez-Martínez MC. Intracellular IL-4, IL-5, and IFN-γ as the main characteristic of CD4+CD30+ T cells after allergen stimulation in patients with vernal keratoconjunctivitis. Molecular vision. 2015;21:443-50. PubMed · PMID: 25999672
- Santacruz C, Linares M, Garfias Y, Loustaunau LM, Pavon L, Perez-Tapia SM, Jimenez-Martinez MC. Expression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immune response in human microbial keratitis. International journal of molecular sciences. 2015;16(3):4850-64. DOI · PubMed · PMID: 25741769
2014 (1)
- Domínguez-López A, Bautista-de Lucio VM, Serafín-López J, Robles-Sánchez E, Garfias Y. Amniotic membrane modulates innate immune response inhibiting PRRs expression and NF-κB nuclear translocation on limbal myofibroblasts. Experimental eye research. 2014;127:215-23. DOI · PubMed · PMID: 25117451
2013 (1)
- Galicia-Carreón J, Santacruz C, Ayala-Balboa J, Robles-Contreras A, Perez-Tapia SM, Garfias Y, Hong E, Jiménez-Martínez MC. An imbalance between frequency of CD4+CD25+FOXP3+ regulatory T cells and CCR4+ and CCR9+ circulating helper T cells is associated with active perennial allergic conjunctivitis. Clinical & developmental immunology. 2013;2013:919742. DOI · PubMed · PMID: 24368924
2007 (1)
- Rojas-Ramos E, Garfias Y, Jiménez-Martínez Mdel C, Martínez-Jiménez N, Zenteno E, Gorocica P, Lascurain R. Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report. Allergy and asthma proceedings. 2007;28(6):659-66. DOI · PubMed · PMID: 18201430
2001 (1)
- Garfias Y, Rojas Ramos E, Ledesma R, Chávez R, Hernández J, Zenteno E. [Advances in the study of immunopathology in atopic disorders]. Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993). 2001;48(3):68-74. PubMed · PMID: 11554126
