Académicos del Departamento
Facultad de Medicina, UNAM
Miguel Angel Jorge Guevara Fonseca

Dr. Miguel Angel Jorge Guevara Fonseca
Investigador Titular “C” TC, SNII III
Departamento de Bioquímica, Facultad de Medicina, UNAM
El Dr. Jorge Guevara es Doctor en Biomedicina Molecular en el CINVESTA-IPN. Realizó estancias doctorales y el posdoctorado en Fisiopatología Molecular de Alzheimer en las universidades McGill y de Montreal, en Montreal, Canadá. Ha sido profesor invitado en varias universidades. Recibió en 1997 el primer lugar en investigación por el Réseau Santé Mentale, FRSQ y Eli Lilly Canadá Inc., Montreal, Canadá. Ha recibido reconocimiento por sus investigaciones, con 6 portadas de revistas científicas.
El Dr. Guevara realiza investigación sobre la fisiopatología molecular de la enfermedad de Alzheimer, con énfasis en los procesos neurodegenerativos asociados al síndrome metabólico. Ha publicado 80 artículos científicos en revistas indexadas y sus citas según Google Scholar son 3250 al día de hoy. El Dr. Guevara creó y dirigió el Laboratorio Experimental de enfermedades Neurodegenerativas, en el Instituto Nacional de Neurología y Neurocirugía, MVS.
En el año 2020 el Dr. Guevara se integró al Comité Nacional de Ciencia, Tecnología e Innovación en Salud Pública (CNCTI-SP) y en el año 2021 al Comité Nacional de Expertos en Moléculas Nuevas de la COFEPRIS. Durante la pandemia de Covid-19, participó en el proceso de evaluación y aprobación científica de las vacunas aplicadas en México.
Actualmente, ocupa el cargo de jefe del Departamento de Bioquímica, en la Facultad de Medicina de la UNAM.
Líneas de Investigación
- Fisiopatología molecular de la Enfermedad de Alzheimer, con énfasis en los procesos neurodegenerativos provocados por el Síndrome Metabólico.
- Enfermedades Neurodegenerativas
Formación académica
Doctorado en Biomedicina Molecular. Centro de Investigaciones y de Estudios Avanzados-IPN (CINVESTAV), CDMX, México. 09/1998
Maestría en Ciencias Fisiológicas. Instituto de Fisiología. Benemérita Universidad Autónoma de Puebla (BUAP). 09/1995
Licenciatura Químico Farmacobiólogo. Facultad de Ciencias Químicas. BUAP. 05/1992
Posdoctorados y estancias
Posdoctorado:
- Universidad de Montreal y Universidad McGill. Montreal, Canadá
Estancias:
- Université de Sciences et Techniques de Lille Flandres-Artrois. Lille, Francia.
- Facultad de Medicina. Universidad de Oviedo, España.
- Departament de Neuropathologie del Institute de Geriatrie de Montréal.
- Departament of Psychiatry. Research Center. Douglas Hospital. McGill University.
Premios y distinciones
- Primer lugar en Investigación por la Réseau Santé Mentale, FRSQ y Eli lilly Canadá Inc. Montreal, Canadá (1997).
- Segundo lugar en Investigación Básica en la XV Reunion Anual de Investigación. Instituto Nacional de Neurología. Mayo del 2000.
- Becario Conacyt para los estudios de Maestría, Doctorado y Posdoctorado.
- Reconocimiento a sus investigaciones con 6 portadas de revistas científicas.
Colaboradores internos o externos
Dra. Estefania Fuentes-Medel, Dra. Karla Rojas, Dr. Edgar Zenteno, Dr. Gonzalo Flores, Dr. Alfonso Díaz, Dr. Samuel Treviño, Dr. Eleazar Ramírez.
Estudiantes
- Guadalupe Michelle López Mendoza (Tesis de Licenciatura)
- Leslie Albarran Hernández (Tesis de Licenciatura)
Publicaciones
41 artículos en 1960-2026
2026 (4)
- Ramírez Hernández E, Netzahualcoyotzi C, Hurtado-Alvarado G, Sánchez JL, Pereyra Morales A, Arredondo-Zamarripa D, Hernández-Zimbrón LF, Papy-Garcia D, Guevara J, Gutiérrez Ponce N, Gomez-Henao W, Garfias Y, et al.. The Effect of Metabolic Syndrome on Alzheimer's Disease: Physical Activity as a Preventive and Therapeutic Measure. Brain sciences. 2026;16(5). DOI · PubMed · PMID: 42192778
- Treviño S, Fuentes E, Venegas B, Muñoz-Arenas G, Vázquez-Roque RA, Galindo-Ramírez F, Avelino-Cruz E, Flores G, Guevara J, Díaz A. Chronic High-Carbohydrate And High-Fat Diet-Induced Metabolic Syndrome Leads To Adrenal Dysfunction, Altered Dendritic Morphology In Limbic Regions, And Anxiety-Like Behaviors In Male Rats. Journal of molecular neuroscience : MN. 2026;76(1). DOI · PubMed · PMID: 41831137
- Juarez D, Venegas B, Molina-Romero D, Vazquez-Roque R, Moreno-Rodriguez JA, Galindo-Ramirez F, Treviño S, Guevara J, Diaz A. Resveratrol Improves Fine Motor Performance and Attenuates Oxidative Stress, GFAP Reactivity, and Purkinje Cell Loss in the Cerebellum of Male Rats After 12, 18, and 24 Months of Treatment. Synapse (New York, N.Y.). 2026;80(2):e70040. DOI · PubMed · PMID: 41635238
- Gonzalez-Cano SI, Juarez-Serrano D, Handal A, Morán Perales JL, Vázquez-Roque RA, Galindo-Ramírez F, Treviño S, Guevara J, Díaz A. Chronic Gallic Acid Treatment Attenuates Hippocampal Neurodegeneration in Aged Rats. Synapse (New York, N.Y.). 2026;80(1):e70036. DOI · PubMed · PMID: 41384328
2025 (2)
- García-Dolores F, Hernández-Torres MA, Fuentes-Medel E, Díaz A, Guevara J, Baltazar-Gaytan E, Aguilar-Hernández L, Nicolini H, Morales-Medina JC, González-Cano SI, de la Cruz F, Gil-Velazco A, et al.. Atrophy and Higher Levels of Inflammatory-Related Markers in the Posterior Cerebellar Lobe Cortex in Chronic Alcohol Use Disorder: A Cross-Sectional Study. Neuropathology and applied neurobiology. 2025;51(2):e70011. DOI · PubMed · PMID: 40141018
- Gonzalez-Cano SI, Peña-Rosas U, Muñoz-Arenas G, Torres-Cinfuentes DM, Treviño S, Moran-Raya C, Flores G, Guevara J, Diaz A. Neuroprotective Effect of Curcumin-Metavanadate in the Hippocampus of Aged Rats. Synapse (New York, N.Y.). 2025;79(1):e70008. DOI · PubMed · PMID: 39748146
2024 (3)
- Kozina A, Herbert-Alonso G, Díaz A, Flores G, Guevara J. Effect of the aggregation state of amyloid-beta (25-35) on the brain oxidative stress in vivo. PloS one. 2024;19(10):e0310258. DOI · PubMed · PMID: 39471144
- Juarez D, Handal-Silva A, Morán-Perales JL, Torres-Cifuentes DM, Flores G, Treviño S, Moreno-Rodriguez A, Guevara J, Diaz A. New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders. Synapse (New York, N.Y.). 2024;78(4):e22301. DOI · PubMed · PMID: 38819491
- Gonzalez-Cano SI, Flores G, Guevara J, Morales-Medina JC, Treviño S, Diaz A. Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases. Neural regeneration research. 2024;19(3):571-577. DOI · PubMed · PMID: 37721286
2023 (2)
- Juarez D, Arteaga I, Cortes H, Vazquez-Roque R, Lopez-Lopez G, Flores G, Treviño S, Guevara J, Diaz A. Chronic resveratrol administration reduces oxidative stress and brain cell loss and improves memory of recognition in old rats. Synapse (New York, N.Y.). 2023;77(4):e22271. DOI · PubMed · PMID: 37130656
- Fuentes E, Venegas B, Muñoz-Arenas G, Moran C, Vazquez-Roque RA, Flores G, Treviño S, Diaz A, Guevara J. High-carbohydrate and fat diet consumption causes metabolic deterioration, neuronal damage, and loss of recognition memory in rats. Journal of chemical neuroanatomy. 2023;129:102237. DOI · PubMed · PMID: 36736441
2022 (2)
- Treviño S, Pulido G, Fuentes E, Handal-Silva A, Moreno-Rodríguez A, Venegas B, Flores G, Guevara J, Díaz A. Effect of cadmium administration on the antioxidant system and neuronal death in the hippocampus of rats. Synapse (New York, N.Y.). 2022;76(9-10):1-16. DOI · PubMed · PMID: 35709361
- Pinzón-Parra CA, Coatl-Cuaya H, Díaz A, Guevara J, Rodríguez-Moreno A, Flores G. Long-term effect of neonatal antagonism of ionotropic glutamate receptors on dendritic spines and cognitive function in rats. Journal of chemical neuroanatomy. 2022;119:102054. DOI · PubMed · PMID: 34839003
2021 (3)
- Mora-Gutiérrez A, Guevara J, Rubio C, Calvillo-Velasco M, Silva-Adaya D, Retana-Márquez S, Espinosa B, Martínez-Valenzuela C, Rubio-Osornio M. Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats. Journal of toxicology. 2021;2021:9983201. DOI · PubMed · PMID: 34858496
- Vazquez-Roque R, Pacheco-Flores M, Penagos-Corzo JC, Flores G, Aguilera J, Treviño S, Guevara J, Diaz A, Venegas B. The C-terminal fragment of the heavy chain of the tetanus toxin (Hc-TeTx) improves motor activity and neuronal morphology in the limbic system of aged mice. Synapse (New York, N.Y.). 2021;75(6):e22193. DOI · PubMed · PMID: 33141999
- Diaz A, Muñoz-Arenas G, Venegas B, Vázquez-Roque R, Flores G, Guevara J, Gonzalez-Vergara E, Treviño S. Metforminium Decavanadate (MetfDeca) Treatment Ameliorates Hippocampal Neurodegeneration and Recognition Memory in a Metabolic Syndrome Model. Neurochemical research. 2021;46(5):1151-1165. DOI · PubMed · PMID: 33559829
2020 (2)
- Muñoz-Arenas G, Pulido G, Treviño S, Vázquez-Roque R, Flores G, Moran C, Handal-Silva A, Guevara J, Venegas B, Díaz A. Effects of metformin on recognition memory and hippocampal neuroplasticity in rats with metabolic syndrome. Synapse (New York, N.Y.). 2020;74(9):e22153. DOI · PubMed · PMID: 32190918
- Diaz A, Muñoz-Arenas G, Caporal-Hernandez K, Vázquez-Roque R, Lopez-Lopez G, Kozina A, Espinosa B, Flores G, Treviño S, Guevara J. Gallic acid improves recognition memory and decreases oxidative-inflammatory damage in the rat hippocampus with metabolic syndrome. Synapse (New York, N.Y.). 2020;75(2):e22186. DOI · PubMed · PMID: 32780904
2019 (1)
- Pulido G, Treviño S, Brambila E, Vazquez-Roque R, Moreno-Rodriguez A, Peña Rosas U, Moran-Perales JL, Handal Silva A, Guevara J, Flores G, Diaz A. The Administration of Cadmium for 2, 3 and 4 Months Causes a Loss of Recognition Memory, Promotes Neuronal Hypotrophy and Apoptosis in the Hippocampus of Rats. Neurochemical research. 2019;44(2):485-497. DOI · PubMed · PMID: 30673958
2018 (2)
- Diaz A, Escobedo C, Treviño S, Chávez R, Lopez-Lopez G, Moran C, Guevara J, Venegas B, Muñoz-Arenas G. Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42. Oxidative medicine and cellular longevity. 2018;2018:1358057. DOI · PubMed · PMID: 30154946
- Ramos-Martinez I, Martínez-Loustalot P, Lozano L, Issad T, Limón D, Díaz A, Perez-Torres A, Guevara J, Zenteno E. Neuroinflammation induced by amyloid β25-35 modifies mucin-type O-glycosylation in the rat's hippocampus. Neuropeptides. 2018;67:56-62. DOI · PubMed · PMID: 29174415
2017 (7)
- Rojas-Gutierrez E, Muñoz-Arenas G, Treviño S, Espinosa B, Chavez R, Rojas K, Flores G, Díaz A, Guevara J. Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration. Synapse (New York, N.Y.). 2017;71(10):e21990. DOI · PubMed · PMID: 28650104
- Diaz A, Treviño S, Vázquez-Roque R, Venegas B, Espinosa B, Flores G, Fernández-G JM, Montaño LF, Guevara J. The aminoestrogen prolame increases recognition memory and hippocampal neuronal spine density in aged mice. Synapse (New York, N.Y.). 2017;71(10):e21987. DOI · PubMed · PMID: 28545157
- Treviño S, Vázquez-Roque RA, López-López G, Perez-Cruz C, Moran C, Handal-Silva A, González-Vergara E, Flores G, Guevara J, Díaz A. Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats. Journal of chemical neuroanatomy. 2017;82:65-75. DOI · PubMed · PMID: 28219715
- Rubio-Osornio M, Orozco-Ibarra M, Díaz-Ruiz A, Brambila E, Boll MC, Monroy-Noyola A, Guevara J, Montes S, Ríos C. Copper sulfate pretreatment prevents mitochondrial electron transport chain damage and apoptosis against MPP(+)-induced neurotoxicity. Chemico-biological interactions. 2017;271:1-8. DOI · PubMed · PMID: 28442376
- Lozano L, Guevara J, Lefebvre T, Ramos-Martinez I, Limón D, Díaz A, Cerón E, Zenteno E. Effect of amyloid-Β (25-35) in hyperglycemic and hyperinsulinemic rats, effects on phosphorylation and O-GlcNAcylation of tau protein. Neuropeptides. 2017;63:18-27. DOI · PubMed · PMID: 28427866
- Silva Adaya D, Aguirre-Cruz L, Guevara J, Ortiz-Islas E. Nanobiomaterials' applications in neurodegenerative diseases. Journal of biomaterials applications. 2017;31(7):953-984. DOI · PubMed · PMID: 28178902
- García-Suástegui WA, Ramos-Chávez LA, Rubio-Osornio M, Calvillo-Velasco M, Atzin-Méndez JA, Guevara J, Silva-Adaya D. The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain. Oxidative medicine and cellular longevity. 2017;2017:4680732. DOI · PubMed · PMID: 28163821
2016 (2)
- Cruz-González T, Cortez-Torres E, Perez-Severiano F, Espinosa B, Guevara J, Perez-Benitez A, Melendez FJ, Díaz A, Ramírez RE. Antioxidative stress effect of epicatechin and catechin induced by Aβ(25-35) in rats and use of the electrostatic potential and the Fukui function as a tool to elucidate specific sites of interaction. Neuropeptides. 2016;59:89-95. DOI · PubMed · PMID: 27118677
- Díaz A, Treviño S, Guevara J, Muñoz-Arenas G, Brambila E, Espinosa B, Moreno-Rodríguez A, Lopez-Lopez G, Peña-Rosas U, Venegas B, Handal-Silva A, Morán-Perales JL, et al.. Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats. Oxidative medicine and cellular longevity. 2016;2016:8725354. DOI · PubMed · PMID: 27069534
2015 (3)
- Treviño S, Aguilar-Alonso P, Flores Hernandez JA, Brambila E, Guevara J, Flores G, Lopez-Lopez G, Muñoz-Arenas G, Morales-Medina JC, Toxqui V, Venegas B, Diaz A. A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats. Synapse (New York, N.Y.). 2015;69(9):421-33. DOI · PubMed · PMID: 26073877
- Rubio-Osornio M, Gorostieta-Salas E, Montes S, Pérez-Severiano F, Rubio C, Gómez C, Ríos C, Guevara J. Epicatechin Reduces Striatal MPP⁺-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity. Oxidative medicine and cellular longevity. 2015;2015:276039. DOI · PubMed · PMID: 26301040
- Luna-Muñoz J, Perry G, Guevara J. Raúl Mena: 1953-2014. Journal of Alzheimer's disease : JAD. 2015;45(2):325-7. DOI · PubMed · PMID: 25757649
2014 (4)
- Lazcano Z, Solis O, Bringas ME, Limón D, Diaz A, Espinosa B, García-Peláez I, Flores G, Guevara J. Unilateral injection of Aβ(25-35) in the hippocampus reduces the number of dendritic spines in hyperglycemic rats. Synapse (New York, N.Y.). 2014;68(12):585-594. DOI · PubMed · PMID: 25049192
- Ortega L, Calvillo M, Luna F, Pérez-Severiano F, Rubio-Osornio M, Guevara J, Limón ID. 17-AAG improves cognitive process and increases heat shock protein response in a model lesion with Aβ25-35. Neuropeptides. 2014;48(4):221-32. DOI · PubMed · PMID: 24819277
- Díaz A, Rojas K, Espinosa B, Chávez R, Zenteno E, Limón D, Guevara J. Aminoguanidine treatment ameliorates inflammatory responses and memory impairment induced by amyloid-beta 25-35 injection in rats. Neuropeptides. 2014;48(3):153-9. DOI · PubMed · PMID: 24703968
- Silva-Adaya D, Gonsebatt ME, Guevara J. Thioredoxin system regulation in the central nervous system: experimental models and clinical evidence. Oxidative medicine and cellular longevity. 2014;2014:590808. DOI · PubMed · PMID: 24723994
2012 (1)
- Solórzano C, Angel Mayoral M, de los Angeles Carlos M, Berumen J, Guevara J, Raúl Chávez F, Mendoza-Hernández G, Agundis C, Zenteno E. Overexpression of glycosylated proteins in cervical cancer recognized by the Machaerocereus eruca agglutinin. Folia histochemica et cytobiologica. 2012;50(3):398-406. DOI · PubMed · PMID: 23042270
2011 (1)
- Rodríguez-Sosa L, Calderón-Rosete G, Calvillo ME, Guevara J, Flores G. Dopaminergic modulation of the caudal photoreceptor in crayfish. Synapse (New York, N.Y.). 2011;65(6):497-504. DOI · PubMed · PMID: 20936686
2005 (2)
- Jiménez-Farfán D, Guevara J, Zenteno E, Hernández-Guerrero JC. Alteration of the sialylation pattern of the murine tooth germ after ethanol exposure. Birth defects research. Part A, Clinical and molecular teratology. 2005;73(12):980-8. DOI · PubMed · PMID: 16323169
- Jiménez-Farfán D, Guevara J, Zenteno E, Malagón H, Hernández-Guerrero JC. EGF-R and erbB-2 in murine tooth development after ethanol exposure. Birth defects research. Part A, Clinical and molecular teratology. 2005;73(2):65-71. DOI · PubMed · PMID: 15690356