Académicos del Departamento

Facultad de Medicina, UNAM

Dr. Ángel Alfonso Zarain Herzberg

Facultad de Medicina. Torre de Investigación, 2do piso
Laboratorio de Biología Molecular
Tel. +52 (55) 56232258

En mi laboratorio de Biología Molecular trabajamos dos líneas de investigación, la primera es referente a la regulación de la expresión de la bomba de calcio SERCA2 y de la Calsecuestrina en el Corazón; la segunda línea de investigación está enfocada a estudiar la regulación transcripcional y epigenética de los genes de SERCA2 y SERCA3 en células cancerosas. Los proyectos reciben financiamiento por parte de CONACyT y DGAPA-PAPIIT-UNAM.

Soy profesor de Bioquímica y Biología Molecular de la carrera de Médico Cirujano y de la Licenciatura en Ciencias Biomédicas de la Facultad de Medicina de la UNAM. Pertenezco a varias sociedades, tales como: Academia Mexicana de Ciencias, Sociedad Mexicana de Bioquímica, American Heart Association, American Society for Biochemistry and Molecular Biology, International Society for Heart Research, International Academy for Cardiovascular Sciences y The New York Academy of Sciences.
He publicado 58 artículos en revistas internacionales con arbitraje y 14 capítulos en libros; dirigido ocho tesis de doctorado, tres de maestría y dos de licenciatura, y he participado como tutor de más de 40 estudiantes de posgrado de los programas de Doctorado en Ciencias Biomédicas y Ciencias Bioquímicas y Ciencias Biológicas de la UNAM.

Experiencia Profesional

Líneas de Investigación

  • Regulación de la expresión de la bomba de calcio SERCA2 y de la Calsecuestrina en el Corazón.
  • Regulación transcripcional y epigenética de los genes de SERCA2 y SERCA3 en células cancerosas.

Trayectoria profesional

  • Investigador Titular “C” de tiempo completo, SNI nivel 2, PRIDE D (1996-a la fecha)
  • Assistant Professor, Departamento de Fisiología, Universidad de Manitoba, Canadá (1990-1996)

Posdoctorados y estancias

  • Estancia Posdoctoral: Charles H. Best Institute, Universidad de Toronto, Canadá (1985-1987) Asesor: Dr. David H. MacLennan
  • Estancia Posdoctoral: Departamento de Fisiología, Universidad de Vermont, EUA (1987-1990) Asesor: Dr. Muthu Periasamy

Formación académica

  • Doctorado en Ciencias Biomédicas, Facultad de Medicina, UNAM (1982-1985)
  • Maestría en Ciencias Biomédicas, Facultad de Medicina, UNAM (1980-1982)
  • Médico Cirujano, Facultad de Medicina, UNAM (1977-1982)

Integrantes del laboratorio

  • Biol. Gabriela Rodríguez Rodríguez, Técnico Académico
  • Dr. Iván Meneses Morales, Asociado Posdoctoral
  • Dr. David de Alba Aguayo, Asociado Posdoctoral

Premios y Distinciones

1985

Fellow Charles H. Best Foundation, Canadá

1987

Fellow American Heart Association, EUA

1990

Fellow Canadian Heart Foundation, Canadá

2012

Premio Miguel Alemán Valdés, México

2014

Premio en Investigación en Nutrición, INCMNSZ, México

Alumnos

Abigail Guzmán Bárcenas

Abigail Guzmán Bárcenas

Tesis de Maestría en Ciencias Bioquímicas

Jorge Fragoso Medina

Jorge Fragoso Medina

Tesis de Doctorado en Ciencias Bioquímicas

Rafael Estrada Avilés

Rafael Estrada Avilés

Tesis de Doctorado en Ciencias Biomédicas

Eduardo Izquierdo Torres

Eduardo Izquierdo Torres

Tesis de Doctorado en Ciencias Bioquímicas

Publicaciones

45 artículos en 1960-2026

2026 (2)

  1. Pérez-Armendariz EM, Zacarías-Lara OJ, Revilla-Monsalve C, Page-Pérez ER, Hernández-Téllez B, Zarain-Herzberg Á, Flores-García CA, Arreola-Rosales R, E Gudiño-Zayas M. Connexin 31.9 is expressed in human pancreatic endocrine beta cells, as well as in exocrine ductal epithelial and vascular endothelial cells. Bioscience reports. 2026;46(8). DOI · PubMed · PMID: 42430215
  2. Hernández-Martínez G, Hernández-Oliveras A, Zarain-Herzberg Á, Santiago-García J. Transcriptional and epigenetic regulation of Ca(2+)-signaling genes in hepatitis B-derived hepatocellular carcinoma and their association with the cancer hallmarks. Bioinformatics advances. 2026;6(1):vbaf331. DOI · PubMed · PMID: 41640621

2025 (1)

  1. Lozano-Arriaga D, Aguilar S, Izquierdo-Torres E, Zarain-Herzberg A. Clinical and epidemiological features of secondary glaucoma in a Mexican Tertiary Ophthalmology Hospital. International ophthalmology. 2025;45(1):336. DOI · PubMed · PMID: 40802212

2024 (2)

  1. Rodríguez-Lima O, García-Gutiérrez P, Jiménez L, Velázquez-Villegas LA, Zarain-Herzberg A, Lazzarini R, Estrada K, Landa A. Taenia solium TAF6 and TAF9 bind to a downstream promoter element present in the Tstbp1 gene core promoter. PloS one. 2024;19(8):e0306633. DOI · PubMed · PMID: 39208271
  2. Hernández-Oliveras A, Zarain-Herzberg A. The role of Ca(2+)-signaling in the regulation of epigenetic mechanisms. Cell calcium. 2024;117:102836. DOI · PubMed · PMID: 37988873

2022 (2)

  1. Izquierdo-Torres E, Hernández-Oliveras A, Lozano-Arriaga D, Zarain-Herzberg Á. Obesity, the other pandemic: linking diet and carcinogenesis by epigenetic mechanisms. The Journal of nutritional biochemistry. 2022;108:109092. DOI · PubMed · PMID: 35718098
  2. Hernández-Oliveras A, Zarain-Herzberg Á. Expression and associated epigenetic mechanisms of the Ca(2+)-signaling genes in breast cancer subtypes and epithelial-to-mesenchymal transition. Journal of cell communication and signaling. 2022;16(3):461-474. DOI · PubMed · PMID: 34762262

2021 (4)

  1. Hernández-Oliveras A, Izquierdo-Torres E, Hernández-Martínez G, Zarain-Herzberg Á, Santiago-García J. Transcriptional and epigenetic landscape of Ca(2+)-signaling genes in hepatocellular carcinoma. Journal of cell communication and signaling. 2021;15(3):433-445. DOI · PubMed · PMID: 33398721
  2. Bernal-Ramírez J, Silva-Platas C, Jerjes-Sánchez C, Ramos-González MR, Vázquez-Garza E, Chapoy-Villanueva H, Ramírez-Rivera A, Zarain-Herzberg Á, García N, García-Rivas G. Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension. Oxidative medicine and cellular longevity. 2021;2021:9912434. DOI · PubMed · PMID: 34239697
  3. Zarain-Herzberg Á, Izquierdo-Torres E, Hernández-Oliveras A, Rodríguez G, Lozano-Arriaga D. Sarcoplasmic reticulum Ca(2+) ATPases genes differential expression in breast cancer cells. Gaceta medica de Mexico. 2021;157(4):343-349. DOI · PubMed · PMID: 35133336
  4. Alves-Figueiredo H, Silva-Platas C, Lozano O, Vázquez-Garza E, Guerrero-Beltrán CE, Zarain-Herzberg A, García-Rivas G. A systematic review of post-translational modifications in the mitochondrial permeability transition pore complex associated with cardiac diseases. Biochimica et biophysica acta. Molecular basis of disease. 2021;1867(1):165992. DOI · PubMed · PMID: 33091565

2020 (2)

  1. Medina-Contreras J, Villalobos-Molina R, Zarain-Herzberg A, Balderas-Villalobos J. Ovariectomized rodents as a menopausal metabolic syndrome model. A minireview. Molecular and cellular biochemistry. 2020;475(1-2):261-276. DOI · PubMed · PMID: 32852713
  2. Izquierdo-Torres E, Hernández-Oliveras A, Fuentes-García G, Zarain-Herzberg Á. Calcium signaling and epigenetics: A key point to understand carcinogenesis. Cell calcium. 2020;91:102285. DOI · PubMed · PMID: 32942140

2019 (4)

  1. Izquierdo-Torres E, Hernández-Oliveras A, Meneses-Morales I, Rodríguez G, Fuentes-García G, Zarain-Herzberg Á. Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms. The international journal of biochemistry & cell biology. 2019;113:37-47. DOI · PubMed · PMID: 31173924
  2. Hernández-Oliveras A, Izquierdo-Torres E, Meneses-Morales I, Rodríguez G, Zarain-Herzberg Á, Santiago-García J. Histone deacetylase inhibitors promote ATP2A3 gene expression in hepatocellular carcinoma cells: p300 as a transcriptional regulator. The international journal of biochemistry & cell biology. 2019;113:8-16. DOI · PubMed · PMID: 31146004
  3. Palacios-González B, Vargas-Castillo A, Velázquez-Villegas LA, Vasquez-Reyes S, López P, Noriega LG, Aleman G, Tovar-Palacio C, Torre-Villalvazo I, Yang LJ, Zarain-Herzberg A, Torres N, et al.. Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice. The Journal of nutritional biochemistry. 2019;68:59-68. DOI · PubMed · PMID: 31030168
  4. Meneses-Morales I, Izquierdo-Torres E, Flores-Peredo L, Rodríguez G, Hernández-Oliveras A, Zarain-Herzberg Á. Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines. Molecular carcinogenesis. 2019;58(6):887-897. DOI · PubMed · PMID: 30657210

2018 (2)

  1. Hernández-Rosas F, Hernández-Oliveras A, Flores-Peredo L, Rodríguez G, Zarain-Herzberg Á, Caba M, Santiago-García J. Histone deacetylase inhibitors induce the expression of tumor suppressor genes Per1 and Per2 in human gastric cancer cells. Oncology letters. 2018;16(2):1981-1990. DOI · PubMed · PMID: 30008892
  2. Fragoso-Medina J, Rodriguez G, Zarain-Herzberg A. The CCAAT box in the proximal SERCA2 gene promoter regulates basal and stress-induced transcription in cardiomyocytes. Molecular and cellular biochemistry. 2018;442(1-2):19-28. DOI · PubMed · PMID: 28884444

2017 (4)

  1. Estrada-Avilés R, Rodríguez G, Zarain-Herzberg A. The cardiac calsequestrin gene transcription is modulated at the promoter by NFAT and MEF-2 transcription factors. PloS one. 2017;12(9):e0184724. DOI · PubMed · PMID: 28886186
  2. García-Castañeda M, Vega AV, Rodríguez R, Montiel-Jaen MG, Cisneros B, Zarain-Herzberg A, Avila G. Functional impact of an oculopharyngeal muscular dystrophy mutation in PABPN1. The Journal of physiology. 2017;595(13):4167-4187. DOI · PubMed · PMID: 28303574
  3. Izquierdo-Torres E, Rodríguez G, Meneses-Morales I, Zarain-Herzberg A. ATP2A3 gene as an important player for resveratrol anticancer activity in breast cancer cells. Molecular carcinogenesis. 2017;56(7):1703-1711. DOI · PubMed · PMID: 28150875
  4. Flores-Peredo L, Rodríguez G, Zarain-Herzberg A. Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells. Molecular carcinogenesis. 2017;56(2):735-750. DOI · PubMed · PMID: 27433831

2016 (3)

  1. Contreras-Leal E, Hernández-Oliveras A, Flores-Peredo L, Zarain-Herzberg Á, Santiago-García J. Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. Molecular carcinogenesis. 2016;55(10):1477-85. DOI · PubMed · PMID: 26331238
  2. Vázquez-Martínez ER, Camacho-Arroyo I, Zarain-Herzberg A, Rodríguez MC, Mendoza-Garcés L, Ostrosky-Wegman P, Cerbón M. Estradiol differentially induces progesterone receptor isoforms expression through alternative promoter regulation in a mouse embryonic hypothalamic cell line. Endocrine. 2016;52(3):618-31. DOI · PubMed · PMID: 26676302
  3. Gustavo Vazquez-Jimenez J, Chavez-Reyes J, Romero-Garcia T, Zarain-Herzberg A, Valdes-Flores J, Manuel Galindo-Rosales J, Rueda A, Guerrero-Hernandez A, Olivares-Reyes JA. Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. Cellular signalling. 2016;28(1):53-9. DOI · PubMed · PMID: 26475209

2015 (1)

  1. Rodríguez-Lima O, García-Gutierrez P, Jiménez L, Zarain-Herzberg Á, Lazzarini R, Landa A. Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1) and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes. PloS one. 2015;10(11):e0141818. DOI · PubMed · PMID: 26529408

2014 (3)

  1. Johnson JS, Kono T, Tong X, Yamamoto WR, Zarain-Herzberg A, Merrins MJ, Satin LS, Gilon P, Evans-Molina C. Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell. The Journal of biological chemistry. 2014;289(47):32798-810. DOI · PubMed · PMID: 25271154
  2. Zarain-Herzberg A, García-Rivas G, Estrada-Avilés R. Regulation of SERCA pumps expression in diabetes. Cell calcium. 2014;56(5):302-10. DOI · PubMed · PMID: 25270119
  3. Palacios-González B, Zarain-Herzberg A, Flores-Galicia I, Noriega LG, Alemán-Escondrillas G, Zariñan T, Ulloa-Aguirre A, Torres N, Tovar AR. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle. Biochimica et biophysica acta. 2014;1841(1):132-40. DOI · PubMed · PMID: 24013029

2012 (1)

  1. Zarain-Herzberg A, Estrada-Avilés R, Fragoso-Medina J. Regulation of sarco(endo)plasmic reticulum Ca2+-ATPase and calsequestrin gene expression in the heart. Canadian journal of physiology and pharmacology. 2012;90(8):1017-28. DOI · PubMed · PMID: 22784385

2011 (1)

  1. Zarain-Herzberg A, Fragoso-Medina J, Estrada-Avilés R. Calcium-regulated transcriptional pathways in the normal and pathologic heart. IUBMB life. 2011;63(10):847-55. DOI · PubMed · PMID: 21901815

2009 (2)

  1. Esquivel-Solís H, Quiñones-Falconi F, Zarain-Herzberg A, Amieva-Fernández RI, López-Vidal Y. Impaired activation of Stat1 and c-Jun as a possible defect in macrophages of patients with active tuberculosis. Clinical and experimental immunology. 2009;158(1):45-54. DOI · PubMed · PMID: 19737230
  2. Reyes-Juárez JL, Zarain-Herzberg A. [Gene therapy for heart failure]. Archivos de cardiologia de Mexico. 2009;79(2):147-56. PubMed · PMID: 19722387

2008 (1)

  1. Moreno-González G, López-Colomé AM, Rodríguez G, Zarain-Herzberg A. Transcription of the chicken Grin1 gene is regulated by the activity of SP3 and NRSF in undifferentiated cells and neurons. Bioscience reports. 2008;28(4):177-88. DOI · PubMed · PMID: 18557703

2007 (1)

  1. Reyes-Juárez JL, Juárez-Rubí R, Rodríguez G, Zarain-Herzberg A. Transcriptional analysis of the human cardiac calsequestrin gene in cardiac and skeletal myocytes. The Journal of biological chemistry. 2007;282(49):35554-63. DOI · PubMed · PMID: 17938175

2006 (2)

  1. Reyes-Juárez JL, Zarain-Herzberg A. [Function and role of the sarcoplasmic reticulum in heart disease]. Archivos de cardiologia de Mexico. 2006;76 Suppl 4:S18-32. PubMed · PMID: 17469332
  2. Zarain-Herzberg A. Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart. Canadian journal of physiology and pharmacology. 2006;84(5):509-21. DOI · PubMed · PMID: 16902596

2005 (1)

  1. Zarain-Herzberg A, Lee-Rivera I, Rodríguez G, López-Colomé AM. Cloning and characterization of the chick NMDA receptor subunit-1 gene. Brain research. Molecular brain research. 2005;137(1-2):235-51. DOI · PubMed · PMID: 15950782

2004 (1)

  1. Zarain-Herzberg A. Transcriptional regulation of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in cardiac myocytes. Journal of muscle research and cell motility. 2004;25(8):609-10. PubMed · PMID: 16285029

2003 (2)

  1. Lee-Rivera I, Zarain-Herzberg A, López-Colomé AM. Developmental expression of N-methyl-D-aspartate glutamate receptor 1 splice variants in the chick retina. Journal of neuroscience research. 2003;73(3):369-83. DOI · PubMed · PMID: 12868071
  2. Delgado-Coello B, Santiago-García J, Zarain-Herzberg A, Mas-Oliva J. Plasma membrane Ca2+-ATPase mRNA expression in murine hepatocarcinoma and regenerating liver cells. Molecular and cellular biochemistry. 2003;247(1-2):177-84. DOI · PubMed · PMID: 12841646

2002 (2)

  1. Zarain-Herzberg A, Alvarez-Fernández G. Sarco(endo)plasmic reticulum Ca2+-ATPase-2 gene: structure and transcriptional regulation of the human gene. TheScientificWorldJournal. 2002;2:1469-83. DOI · PubMed · PMID: 12805933
  2. Zarain-Herzberg A, Rupp H. Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a target. Expert opinion on investigational drugs. 2002;11(3):345-56. DOI · PubMed · PMID: 11866664

1999 (1)

  1. Zarain-Herzberg A, Rupp H. Transcriptional modulators targeted at fuel metabolism of hypertrophied heart. The American journal of cardiology. 1999;83(12A):31H-37H. DOI · PubMed · PMID: 10750584
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