Dr. Juan Cuauhtémoc Díaz Zagoya

Académicos del Departamento

Facultad de Medicina, UNAM

Edificio D, 1er. Piso, laboratorio 11

Teléfonos, laboratorio: 5255 5623 2174, oficina: 5255 1793 0753

Investigación de interés: Metabolismo de los lípidos: estudio en modelos animales y en casos clínicos en que está alterado.

Experiencia Profesional

Líneas de Investigación

Las estatinas, inhibidoras de la biosíntesis de colesterol: análisis de sus efectos adversos en la función y morfología de las mitocondrias de hepatocitos de ratones con dieta rica en colesterol.

Trayectoria profesional

Profesor Titular C de TC definitivo
Pride D
Sistema Nacional de Investigadores, nivel 1, 1986-2023
Facultad de Medicina UNAM desde 1959

Formación académica

Programa de Doctorado en Ciencias Químicas (Bioquímica), Facultad de Química, UNAM, 1065-968, aprobado en examen de conocimientos: junio 27, 1979
Diplomado en Reproductive Biochemistry in Obstetrics and Gynecology, Washington University School of Medicine, 1977-1978
Licenciatura de Médico Cirujano, Facultad de Medicina UNAM. 1957-1962

Posdoctorados y estancias

En: Washington University School of Medicine, Saint Louis, Mo., USA, enero 1977-diciembre 978.
En División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, septiembre 1994-marzo 1995

Proyectos en los que participa

Participación en proyectos, en colaboración, con el grupo de investigadores de la División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco

Colaboradores internos o externos

Dr. Andrés Castell, Departamento de Biología Celular y Tisular
Dra. Isela Esther Juárez Rojop, Universidad Juárez Autónoma de Tabasco
Dr. Jorge Luis Blé Castillo, Universidad Juárez Autónoma de Tabasco
Dr. Alejandro Marín Medina, Universidad de Guadalajara

Integrantes del laboratorio

Juan Cuauhtémoc Díaz Zagoya
Rodrigo Miranda Zamora

Distinciones

Mención Honorífica en tesis de licenciatura, agosto 25, 1954
Medalla y Diploma en Reconocimiento al Mérito Universitario por 50 años de Labor Académica, Universidad Nacional Autónoma de México, mayo 11, 2011
Designación como Socio Emérito, Sociedad Mexicana de Nutrición y Endocrinología, 2012
Diploma de la Asociación Civil Prevención, Bienestar y Salud, Ciudad de México, por haber sido el Presidente fundador de dicha asociación, abril 27, 2019
Diploma de la División Académica de Ciencias de la Salud Universidad Juárez Autónoma de Tabasco, en reconocimiento de servicios académicos, marzo 25, 2019
Diploma y medalla por 60 años de labor académica, Facultad de Medicina, UNAM, 2021

Alumnos

Jared González Escandón

AFINES

Diego Ordaz Mayoral

AFINES

Alberto Vargas Morales

AFINES

Verónica Pablo Mancilla

AFINES

Publicaciones

Reyes-López Z, Olvera-Hernández V, Ramos-García M, Méndez JD, Guzmán-Priego CG, Martínez-López MC, García-Vázquez C, Alvarez-Villagomez CS, Juárez-Rojop IE, Díaz-Zagoya JC and Ble-Castillo JL. Effects of Sucralose Supplementation on Glycemic Response, Appetite, and Gut Microbiota in Subjects with Overweight or Obesity: A Randomized Crossover Study Protocol. (2024) Methods Protoc. 7, Pubmed Methods Protoc PMC Article

Martínez-Magaña JJ, Genis-Mendoza AD, Gallegos-Silva I, López-Narváez ML, Juárez-Rojop IE, Diaz-Zagoya JC, Tovilla-Zárate CA, González-Castro TB, Nicolini H and Solis-Medina A. Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats. (2024) Nutrients. 16, Pubmed Nutrients PMC Article

Díaz-Zagoya JC, Marín-Medina A, Zetina-Esquivel AM, Blé-Castillo JL, Castell-Rodríguez AE, Juárez-Rojop IE and Miranda-Zamora R. Effects of high rosuvastatin doses on hepatocyte mitochondria of hypercholesterolemic mice. (2021) Sci Rep. 11, 15809 Pubmed Sci Rep PMC Article

Ramos-García M, Ble-Castillo JL, García-Vázquez C, Tovilla-Zárate CA, Juárez-Rojop IE, Olvera-Hernández V, Genis-Mendoza AD, Córdova-Uscanga R, Álvarez-González CA and Díaz-Zagoya JC. Effects of Non-Nutritive Sweeteners on Energy Intake, Body Weight and Postprandial Glycemia in Healthy and with Altered Glycemic Response Rats. (2021) Foods. 10, Pubmed Foods PMC Article

García-Vázquez C, Ble-Castillo JL, Arias-Córdova Y, Córdova-Uscanga R, Tovilla-Zárate CA, Juárez-Rojop IE, Olvera-Hernández V, Alvarez-Villagomez CS, Nolasco-Coleman AM and Díaz-Zagoya JC. Effects of Resistant Starch Ingestion on Postprandial Lipemia and Subjective Appetite in Overweight or Obese Subjects. (2019) Int J Environ Res Public Health. 16, Pubmed Int J Environ Res Public Health PMC Article

Marín-Medina A, Ruíz-Hidalgo G, Blé-Castillo JL, Zetina-Esquivel AM, Zamora RM, Juárez-Rojop IE and Díaz-Zagoya JC. Combined Effect of Diosgenin Along with Ezetimibe or Atorvastatin on the Fate of Labelled Bile Acid and Cholesterol in Hypercholesterolemic Rats. (2019) Int J Environ Res Public Health. 16, Pubmed Int J Environ Res Public Health PMC Article

Solis-Medina A, Martínez-Magaña JJ, Quintanar-Jurado V, Gallegos-Silva I, Juárez-Rojop IE, Tovilla-Zárate CA, Díaz-Zagoya JC, Hernández-Díaz Y, González-Castro TB, López-Narváez ML, Genis-Mendoza AD and Nicolini H. Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats. (2018) Metab Brain Dis. 33, 2031-2038 Pubmed Metab Brain Dis

Ble-Castillo JL, Juárez-Rojop IE, Tovilla-Zárate CA, García-Vázquez C, Servin-Cruz MZ, Rodríguez-Hernández A, Araiza-Saldaña CI, Nolasco-Coleman AM and Díaz-Zagoya JC. Acute Consumption of Resistant Starch Reduces Food Intake but Has No Effect on Appetite Ratings in Healthy Subjects. (2017) Nutrients. 9, Pubmed Nutrients PMC Article

Suarez-Mendez S, Tovilla-Zarate CA, Ortega-Varela LF, Bermudez-Ocaña DY, Blé-Castillo JL, González-Castro TB, Zetina-Esquivel AM, Diaz-Zagoya JC and Esther Juárez-Rojop I. Isobolographic Analyses of Proglumide-Celecoxib Interaction in Rats with Painful Diabetic Neuropathy. (2017) Drug Dev Res. 78, 116-123 Pubmed Drug Dev Res

Miranda-Osorio PH, Castell-Rodríguez AE, Vargas-Mancilla J, Tovilla-Zárate CA, Ble-Castillo JL, Aguilar-Domínguez DE, Juárez-Rojop IE and Díaz-Zagoya JC. Protective Action of Carica papaya on β-Cells in Streptozotocin-Induced Diabetic Rats. (2016) Int J Environ Res Public Health. 13, Pubmed Int J Environ Res Public Health PMC Article

Jiménez-Domínguez G, Ble-Castillo JL, Aparicio-Trápala MA, Juárez-Rojop IE, Tovilla-Zárate CA, Ble-Castillo DJ, García-Vázquez C, Olvera-Hernández V, Pérez-Pimienta B, Diaz-Zagoya JC and Mendez JD. Effects of Acute Ingestion of Native Banana Starch on Glycemic Response Evaluated by Continuous Glucose Monitoring in Obese and Lean Subjects. (2015) Int J Environ Res Public Health. 12, 7491-505 Pubmed Int J Environ Res Public Health PMC Article

Juárez-Rojop IE, Morales-Hernández PE, Tovilla-Zárate CA, Bermúdez-Ocaña DY, Torres-Lopez JE, Ble-Castillo JL, Díaz-Zagoya JC and Granados-Soto V. Celecoxib reduces hyperalgesia and tactile allodynia in diabetic rats. (2015) Pharmacol Rep. 67, 545-52 Pubmed Pharmacol Rep

Jiménez-Santos MA, Juárez-Rojop IE, Tovilla-Zárate CA, Espinosa-García MT, Juárez-Oropeza MA, Ramón-Frías T, Bermúdez-Ocaña DY and Díaz-Zagoya JC. Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet. (2014) Lipids Health Dis. 13, 22 Pubmed Lipids Health Dis PMC Article

Juárez-Rojop IE, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T and Bermúdez-Ocaña DY. Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. (2012) BMC Complement Altern Med. 12, 236 Pubmed BMC Complement Altern Med PMC Article

Ble-Castillo JL, Aparicio-Trapala MA, Juárez-Rojop IE, Torres-Lopez JE, Mendez JD, Aguilar-Mariscal H, Olvera-Hernández V, Palma-Cordova LC and Diaz-Zagoya JC. Differential effects of high-carbohydrate and high-fat diet composition on metabolic control and insulin resistance in normal rats. (2012) Int J Environ Res Public Health. 9, 1663-76 Pubmed Int J Environ Res Public Health PMC Article

Bermúdez-Ocaña DY, Aguilar-Mariscal H, Frías TR, Blé-Castillo JL, Flores-Murrieta FJ, Díaz-Zagoya JC, Granados-Soto V and Juárez-Rojop IE. Proglumide enhances the antinociceptive effect of cyclooxygenase inhibitors in diabetic rats in the formalin test. (2011) Eur J Pharmacol. 664, 8-13 Pubmed Eur J Pharmacol

Ble-Castillo JL, Aparicio-Trápala MA, Francisco-Luria MU, Córdova-Uscanga R, Rodríguez-Hernández A, Méndez JD and Díaz-Zagoya JC. Effects of native banana starch supplementation on body weight and insulin sensitivity in obese type 2 diabetics. (2010) Int J Environ Res Public Health. 7, 1953-62 Pubmed Int J Environ Res Public Health PMC Article

Ble-Castillo JL, Cleva-Villanueva G, Díaz-Zagoya JC, Medina-Santillán R, Rubio-Arias HO and Méndez JD. Effects of alpha-tocopherol on oxidative status and metabolic profile in overweight women. (2007) Int J Environ Res Public Health. 4, 260-7 Pubmed Int J Environ Res Public Health PMC Article

Torres-López JE, Juárez-Rojop IE, Granados-Soto V, Diaz-Zagoya JC, Flores-Murrieta FJ, Ortíz-López JU and Cruz-Vera J. Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats. (2007) Neuropharmacology. 52, 788-95 Pubmed Neuropharmacology

Juárez-Rojop IE, Granados-Soto V, Díaz-Zagoya JC, Flores-Murrieta FJ and Torres-López JE. Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response. (2006) Pain. 122, 118-25 Pubmed Pain

Torres-Durán PV, Paredes-Carbajal MC, Mascher D, Zamora-González J, Díaz-Zagoya JC and Juárez-Oropeza MA. Protective effect of Arthrospira maxima on fatty acid composition in fatty liver. (2006) Arch Med Res. 37, 479-83 Pubmed Arch Med Res

Mascher D, Paredes-Carbajal MC, Torres-Durán PV, Zamora-González J, Díaz-Zagoya JC and Juárez-Oropeza MA. Ethanolic extract of Spirulina maxima alters the vasomotor reactivity of aortic rings from obese rats. (2006) Arch Med Res. 37, 50-7 Pubmed Arch Med Res

Ble-Castillo JL, Carmona-Díaz E, Méndez JD, Larios-Medina FJ, Medina-Santillán R, Cleva-Villanueva G and Díaz-Zagoya JC. Effect of alpha-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics. (2005) Biomed Pharmacother. 59, 290-5 Pubmed Biomed Pharmacother

Blé-Castillo JL, Rodríguez-Hernández A, Miranda-Zamora R, Juárez-Oropeza MA and Díaz-Zagoya JC. Arthrospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice. (2002) Life Sci. 70, 2665-73 Pubmed Life Sci

Acosta-Patiño JL, Jiménez-Balderas E, Juárez-Oropeza MA and Díaz-Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on Type 2 diabetic patients with moderately high blood glucose levels. (2001) J Ethnopharmacol. 77, 99-101 Pubmed J Ethnopharmacol

Rodríguez-Hernández A, Blé-Castillo JL, Juárez-Oropeza MA and Díaz-Zagoya JC. Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes. (2001) Life Sci. 69, 1029-37 Pubmed Life Sci

Paredes-Carbajal MC, Torres-Durán PV, Díaz-Zagoya JC, Mascher D and Juárez-Oropeza MA. Effects of the ethanolic extract of Spirulina maxima on endothelium dependent vasomotor responses of rat aortic rings. (2001) J Ethnopharmacol. 75, 37-44 Pubmed J Ethnopharmacol

Cuevas-Covarrubias SA, Valdes-Flores M, Rivera-Vega MR, Diaz-Zagoya JC and Kofman-Alfaro SH. Ichthyosis vulgaris and X-linked ichthyosis: simultaneous segregation in the same family. (1999) Acta Derm Venereol. 79, 494-5 Pubmed Acta Derm Venereol

Cuevas-Covarrubias SA, Díaz-Zagoya JC, Rivera-Vega MR, Beirana A, Carrasco E, Orozco E and Kofman-Alfaro SH. Higher prevalence of X-linked ichthyosis vs. ichthyosis vulgaris in Mexico. (1999) Int J Dermatol. 38, 555-6 Pubmed Int J Dermatol

Cuevas-Covarrubias SA, Valdes-Flores M, Orozco Orozco E, Díaz-Zagoya JC and Kofman-Alfaro SH. Most "sporadic" cases of X-linked ichthyosis are not de novo mutations. (1999) Acta Derm Venereol. 79, 143-4 Pubmed Acta Derm Venereol

Torres-Durán PV, Miranda-Zamora R, Paredes-Carbajal MC, Mascher D, Blé-Castillo J, Díaz-Zagoya JC and Juárez-Oropeza MA. Studies on the preventive effect of Spirulina maxima on fatty liver development induced by carbon tetrachloride, in the rat. (1999) J Ethnopharmacol. 64, 141-7 Pubmed J Ethnopharmacol

Miranda-Duarte A, Valdés-Flores M, Miranda-Zamora R, Díaz-Zagoya JC, Kofman-Alfaro SH and Cuevas-Covarrubias SA. Steroid sulfatase activity in leukocytes: a comparative study in 45,X; 46,Xi(Xq) and carriers of steroid sulfatase deficiency. (1999) Biochem Mol Biol Int. 47, 137-42 Pubmed Biochem Mol Biol Int

Cuevas-Covarrubias SA, Valdés-Flores M, Orozco Orozco E, Díaz-Zagoya JC and Kofman-Alfaro SH. Are atopy and palm-sole hyperlinearity clinical tools in the differential diagnosis between ichthyosis vulgaris and X-linked ichthyosis?. (1998) J Dermatol. 25, 556-7 Pubmed J Dermatol

Torres-Durán PV, Miranda-Zamora R, Paredes-Carbajal MC, Mascher D, Díaz-Zagoya JC and Juárez-Oropeza MA. Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat. (1998) Biochem Mol Biol Int. 44, 787-93 Pubmed Biochem Mol Biol Int

Cuevas-Covarrubias SA, Kofman-Alfaro SH, Maya-Núñez G, Díaz-Zagoya JC and Orozco Orozco E. X-linked ichthyosis in Mexico: high frequency of deletions in the steroid sulfatase encoding gene. (1997) Am J Med Genet. 72, 415-6 Pubmed Am J Med Genet

Cuevas-Covarrubias SA, Kofman-Alfaro SH, Palencia AB and Díaz-Zagoya JC. Accuracy of the clinical diagnosis of recessive X-linked ichthyosis vs ichthyosis vulgaris. (1996) J Dermatol. 23, 594-7 Pubmed J Dermatol

Cuevas-Covarrubias SA, Kofman-Alfaro SH, Rivera-Vega MD, Palencia AB and Díaz-Zagoya JC. Inguinal hernia in recessive X-linked ichthyosis. (1994) J Dermatol. 21, 985 Pubmed J Dermatol

Cuevas-Covarrubias SA, Juárez-Oropeza MA, Miranda-Zamora R and Díaz-Zagoya JC. Comparative analysis of human steroid sulfatase activity in prepubertal and postpubertal males and females. (1993) Biochem Mol Biol Int. 30, 691-5 Pubmed Biochem Mol Biol Int

Echegoyen S, Oliva EB, Sepulveda J, Díaz-Zagoya JC, Espinosa-García MT, Pardo JP and Martínez F. Cholesterol increase in mitochondria: its effect on inner-membrane functions, submitochondrial localization and ultrastructural morphology. (1993) Biochem J. 289 ( Pt 3), 703-8 Pubmed Biochem J PMC Article

Vazquez-Alcantara MA, Menjivar M, Garcia GA, Díaz-Zagoya JC and Garza-Flores J. Long-acting estrogenic responses of estradiol fatty acid esters. (1989) J Steroid Biochem. 33, 1111-8 Pubmed J Steroid Biochem

Mendoza-Hernández G, López-Solache I, Rendón JL, Díaz-Sánchez V and Díaz-Zagoya JC. 17 beta-hydroxysteroid dehydrogenase activity in canine pancreas. (1988) Biochem Biophys Res Commun. 152, 376-82 Pubmed Biochem Biophys Res Commun

Mendoza-Hernández G, López-Solache I and Díaz-Zagoya JC. Periodate-oxidized NADP+ is a powerful inhibitor of human placental estradiol-17 beta dehydrogenase. (1987) Biochem Biophys Res Commun. 146, 645-51 Pubmed Biochem Biophys Res Commun

Vázquez-Alcántara MA, Juárez-Oropeza MA, Zamora RM, Díaz-Zagoya JC and Garza-Flores J. Synthesis and biological assessment of long-acting estradiol fatty acid esters in ovariectomized rats. (1985) J Steroid Biochem. 23, 599-602 Pubmed J Steroid Biochem

Mendoza-Hernández G, Rendón JL and Díaz-Zagoya JC. A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta. (1985) Biochem Biophys Res Commun. 126, 477-81 Pubmed Biochem Biophys Res Commun

Mendoza-Hernández G, Calcagno M, Sánchez-Nuncio HR and Díaz-Zagoya JC. Dehydroepiandrosterone is a substrate for estradiol 17 beta-dehydrogenase from human placenta. (1984) Biochem Biophys Res Commun. 119, 83-7 Pubmed Biochem Biophys Res Commun

Diaz-Zagoya JC and Arias F. Synthesis and catabolism of progesterone in placentas from normotensive and severely hypertensive patients before and after parturition. (1981) Am J Obstet Gynecol. 141, 637-40 Pubmed Am J Obstet Gynecol

Diaz-Zagoya JC, Wiest WG and Arias F. Metabolism of progesterone by placentas from several mammalian species in vitro. (1979) Am J Obstet Gynecol. 135, 809-13 Pubmed Am J Obstet Gynecol

Diaz-Zagoya JC, Wiest WG and Arias F. 20 alpha-Hydroxysteroid oxidoreductase activity and 20 alpha-dihydroprogesterone concentration in human placenta before and after parturition. (1979) Am J Obstet Gynecol. 133, 673-6 Pubmed Am J Obstet Gynecol

Díaz-Zagoya JC, Hurtado ME and González J. Alteration of cholesterol synthesis in rat liver as induced by 4-methyl-5-hydroxy valeric acid. (1976) Experientia. 32, 1138-40 Pubmed Experientia

Calcagno M, Díaz Zagoya JC and Gascón Lozano A. Immunosedimentation: a combination of ultracentrifugation using acrylamide gel followed by immunodiffusion in agarose gel. (1976) Anal Biochem. 73, 386-90 Pubmed Anal Biochem

Díaz Zagoya JC, Laguna J and Guzmán-García J. Studies on the regulation of cholesterol metabolism by the use of the structural analogue, diosgenin. (1971) Biochem Pharmacol. 20, 3473-80 Pubmed Biochem Pharmacol

Díaz-Zagoya JC, Asenjo-Barrón JC, Cárdenas-Vázquez R, Martínez F and Juárez-Oropeza MA. Comparative toxicity of high doses of vastatins currently used by clinicians, in CD-1 male mice fed with a hypercholesterolemic diet. (1999) Life Sci. 65, 947-56 Pubmed Life Sci

Blé-Castillo JL, Díaz-Zagoya JC and Méndez JD. [Is vitamin-E supplementation beneficial or harmful?]. (2008) Gac Med Mex. 144, 147-54 Pubmed Gac Med Mex

Ramos-Villalón SA, Vázquez-López E, Damián-Pérez R, López-Estrada D and Díaz-Zagoya JC. [Pattern of bone fractures in motorcycle accidents in a High Specialty Hospital]. (2020) Acta Ortop Mex. 34, 376-381 Pubmed Acta Ortop Mex

Paredes-Carbajal MC, Torres-Durán PV, Díaz-Zagoya JC, Mascher D and Juárez-Oropeza MA. Effects of dietary Spirulina maxima on endothelium dependent vasomotor responses of rat aortic rings. (1997) Life Sci. 61, PL 211-9 Pubmed Life Sci

Asenjo-Barrón JC, Cárdenas-Vásquez R, Martínez F, Juárez-Oropeza MA and Díaz-Zagoya JC. High lovastatin doses combined with hypercholesterolemic diet induce hepatic damage and are lethal to the CD-1 mouse. (1999) Life Sci. 64, 2155-61 Pubmed Life Sci

Cuevas-Covarrubias SA, Kofman-Alfaro S, Orozco Orozco E and Diaz-Zagoya JC. The biochemical identification of carrier state in mothers of sporadic cases of X-linked recessive ichthyosis. (1995) Genet Couns. 6, 103-7 Pubmed Genet Couns

Cuevas-Covarrubias SA, Rojo-Callejas F, Juárez-Oropeza MA and Díaz-Zagoya JC. [Erythrocyte fatty acids in children with severe protein-calorie malnutrition]. (1994) Rev Invest Clin. 46, 197-201 Pubmed Rev Invest Clin

González de Rivera C, Miranda-Zamora R, Díaz-Zagoya JC and Juárez-Oropeza MA. Preventive effect of Spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report. (1993) Life Sci. 53, 57-61 Pubmed Life Sci

Cuevas-Covarrubias SA, Miranda-Zamora R, Juarez-Oropeza MA and Diaz-Zagoya JC. Comparative analysis of erythrocyte fatty acid composition in a sample of Mexico City children and young adults on a free diet. (1993) Arch Med Res. 24, 327-31 Pubmed Arch Med Res

Juarez-Oropeza MA, Diaz-Zagoya JC and Rabinowitz JL. In vivo and in vitro studies of hypocholesterolemic effects of diosgenin in rats. (1987) Int J Biochem. 19, 679-83 Pubmed Int J Biochem