Académicos del Departamento
Facultad de Medicina, UNAM
Dr. Ángel Alfonso Zarain Herzberg
Facultad de Medicina. Torre de Investigación, 2do piso
Laboratorio de Biología Molecular
Tel. +52 (55) 56232258
En mi laboratorio de Biología Molecular trabajamos dos líneas de investigación, la primera es referente a la regulación de la expresión de la bomba de calcio SERCA2 y de la Calsecuestrina en el Corazón; la segunda línea de investigación está enfocada a estudiar la regulación transcripcional y epigenética de los genes de SERCA2 y SERCA3 en células cancerosas. Los proyectos reciben financiamiento por parte de CONACyT y DGAPA-PAPIIT-UNAM.
Soy profesor de Bioquímica y Biología Molecular de la carrera de Médico Cirujano y de la Licenciatura en Ciencias Biomédicas de la Facultad de Medicina de la UNAM. Pertenezco a varias sociedades, tales como: Academia Mexicana de Ciencias, Sociedad Mexicana de Bioquímica, American Heart Association, American Society for Biochemistry and Molecular Biology, International Society for Heart Research, International Academy for Cardiovascular Sciences y The New York Academy of Sciences.
He publicado 58 artículos en revistas internacionales con arbitraje y 14 capítulos en libros; dirigido ocho tesis de doctorado, tres de maestría y dos de licenciatura, y he participado como tutor de más de 40 estudiantes de posgrado de los programas de Doctorado en Ciencias Biomédicas y Ciencias Bioquímicas y Ciencias Biológicas de la UNAM.
Experiencia Profesional
Líneas de Investigación
- Regulación de la expresión de la bomba de calcio SERCA2 y de la Calsecuestrina en el Corazón.
- Regulación transcripcional y epigenética de los genes de SERCA2 y SERCA3 en células cancerosas.
Trayectoria profesional
- Investigador Titular “C” de tiempo completo, SNI nivel 2, PRIDE D (1996-a la fecha)
- Assistant Professor, Departamento de Fisiología, Universidad de Manitoba, Canadá (1990-1996)
Posdoctorados y estancias
- Estancia Posdoctoral: Charles H. Best Institute, Universidad de Toronto, Canadá (1985-1987) Asesor: Dr. David H. MacLennan
- Estancia Posdoctoral: Departamento de Fisiología, Universidad de Vermont, EUA (1987-1990) Asesor: Dr. Muthu Periasamy
Formación académica
- Doctorado en Ciencias Biomédicas, Facultad de Medicina, UNAM (1982-1985)
- Maestría en Ciencias Biomédicas, Facultad de Medicina, UNAM (1980-1982)
- Médico Cirujano, Facultad de Medicina, UNAM (1977-1982)
Integrantes del laboratorio
- Biol. Gabriela Rodríguez Rodríguez, Técnico Académico
- Dr. Iván Meneses Morales, Asociado Posdoctoral
- Dr. David de Alba Aguayo, Asociado Posdoctoral
Premios y Distinciones
1985
Fellow Charles H. Best Foundation, Canadá
1987
Fellow American Heart Association, EUA
1990
Fellow Canadian Heart Foundation, Canadá
2012
Premio Miguel Alemán Valdés, México
2014
Premio en Investigación en Nutrición, INCMNSZ, México
Alumnos
Abigail Guzmán Bárcenas
Tesis de Maestría en Ciencias Bioquímicas
Jorge Fragoso Medina
Tesis de Doctorado en Ciencias Bioquímicas
Rafael Estrada Avilés
Tesis de Doctorado en Ciencias Biomédicas
Eduardo Izquierdo Torres
Tesis de Doctorado en Ciencias Bioquímicas
Publicaciones
The role of Ca-signaling in the regulation of epigenetic mechanisms.
(2024) Cell Calcium. 117, 102836
Pubmed
Cell Calcium
Obesity, the other pandemic: linking diet and carcinogenesis by epigenetic mechanisms.
(2022) J Nutr Biochem. 108, 109092
Pubmed
J Nutr Biochem
Expression and associated epigenetic mechanisms of the Ca-signaling genes in breast cancer subtypes and epithelial-to-mesenchymal transition.
(2022) J Cell Commun Signal. 16, 461-474
Pubmed
J Cell Commun Signal
PMC Article
Transcriptional and epigenetic landscape of Ca-signaling genes in hepatocellular carcinoma.
(2021) J Cell Commun Signal. 15, 433-445
Pubmed
J Cell Commun Signal
PMC Article
Calcium signaling and epigenetics: A key point to understand carcinogenesis.
(2020) Cell Calcium. 91, 102285
Pubmed
Cell Calcium
Histone deacetylase inhibitors promote ATP2A3 gene expression in hepatocellular carcinoma cells: p300 as a transcriptional regulator.
(2019) Int J Biochem Cell Biol. 113, 8-16
Pubmed
Int J Biochem Cell Biol
Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms.
(2019) Int J Biochem Cell Biol. 113, 37-47
Pubmed
Int J Biochem Cell Biol
Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
(2019) Mol Carcinog. 58, 887-897
Pubmed
Mol Carcinog
Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice.
(2019) J Nutr Biochem. 68, 59-68
Pubmed
J Nutr Biochem
Histone deacetylase inhibitors induce the expression of tumor suppressor genes Per1 and Per2 in human gastric cancer cells.
(2018) Oncol Lett. 16, 1981-1990
Pubmed
Oncol Lett
PMC Article
The CCAAT box in the proximal SERCA2 gene promoter regulates basal and stress-induced transcription in cardiomyocytes.
(2018) Mol Cell Biochem. 442, 19-28
Pubmed
Mol Cell Biochem
ATP2A3 gene as an important player for resveratrol anticancer activity in breast cancer cells.
(2017) Mol Carcinog. 56, 1703-1711
Pubmed
Mol Carcinog
Functional impact of an oculopharyngeal muscular dystrophy mutation in PABPN1.
(2017) J Physiol. 595, 4167-4187
Pubmed
J Physiol
PMC Article
Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
(2017) Mol Carcinog. 56, 735-750
Pubmed
Mol Carcinog
Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines.
(2016) Mol Carcinog. 55, 1477-85
Pubmed
Mol Carcinog
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.
(2016) Cell Signal. 28, 53-9
Pubmed
Cell Signal
Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.
(2014) J Biol Chem. 289, 32798-810
Pubmed
J Biol Chem
PMC Article
Regulation of SERCA pumps expression in diabetes.
(2014) Cell Calcium. 56, 302-10
Pubmed
Cell Calcium
Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle.
(2014) Biochim Biophys Acta. 1841, 132-40
Pubmed
Biochim Biophys Acta
Regulation of sarco(endo)plasmic reticulum Ca2+-ATPase and calsequestrin gene expression in the heart.
(2012) Can J Physiol Pharmacol. 90, 1017-28
Pubmed
Can J Physiol Pharmacol
PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.
(2012) Mol Endocrinol. 26, 257-71
Pubmed
Mol Endocrinol
PMC Article
Calcitonin gene-related peptide restores disrupted excitation-contraction coupling in myotubes expressing central core disease mutations in RyR1.
(2011) J Physiol. 589, 4649-69
Pubmed
J Physiol
PMC Article
Calcium-regulated transcriptional pathways in the normal and pathologic heart.
(2011) IUBMB Life. 63, 847-55
Pubmed
IUBMB Life
Transcription of the chicken Grin1 gene is regulated by the activity of SP3 and NRSF in undifferentiated cells and neurons.
(2008) Biosci Rep. 28, 177-88
Pubmed
Biosci Rep
Transcriptional analysis of the human cardiac calsequestrin gene in cardiac and skeletal myocytes.
(2007) J Biol Chem. 282, 35554-63
Pubmed
J Biol Chem
Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart.
(2006) Can J Physiol Pharmacol. 84, 509-21
Pubmed
Can J Physiol Pharmacol
Cloning and characterization of the chick NMDA receptor subunit-1 gene.
(2005) Brain Res Mol Brain Res. 137, 235-51
Pubmed
Brain Res Mol Brain Res
Plasma membrane Ca2+-ATPase mRNA expression in murine hepatocarcinoma and regenerating liver cells.
(2003) Mol Cell Biochem. 247, 177-84
Pubmed
Mol Cell Biochem
Sarco(endo)plasmic reticulum Ca2+-ATPase-2 gene: structure and transcriptional regulation of the human gene.
(2002) ScientificWorldJournal. 2, 1469-83
Pubmed
ScientificWorldJournal
PMC Article
Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a target.
(2002) Expert Opin Investig Drugs. 11, 345-56
Pubmed
Expert Opin Investig Drugs
Taenia solium TAF6 and TAF9 bind to a downstream promoter element present in the Tstbp1 gene core promoter.
(2024) PLoS One. 19, e0306633
Pubmed
PLoS One
PMC Article
Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension.
(2021) Oxid Med Cell Longev. 2021, 9912434
Pubmed
Oxid Med Cell Longev
PMC Article
Sarcoplasmic reticulum Ca ATPases genes differential expression in breast cancer cells.
(2021) Gac Med Mex. 157, 343-349
Pubmed
Gac Med Mex
The cardiac calsequestrin gene transcription is modulated at the promoter by NFAT and MEF-2 transcription factors.
(2017) PLoS One. 12, e0184724
Pubmed
PLoS One
PMC Article
Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1) and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes.
(2015) PLoS One. 10, e0141818
Pubmed
PLoS One
PMC Article
Transcriptional regulation of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in cardiac myocytes.
(2004) J Muscle Res Cell Motil. 25, 609-10
Pubmed
J Muscle Res Cell Motil
[Function and role of the sarcoplasmic reticulum in heart disease].
(2006) Arch Cardiol Mex. 76 Suppl 4, S18-32
Pubmed
Arch Cardiol Mex
